Results 71 to 80 of about 52,725 (307)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Increased harvest frequency improves biomass yields and nutrient removal on a filamentous algae nutrient scrubber

, 2020
© 2020 Elsevier B.V. Filamentous algae nutrient scrubbers (FANS) are artificial flow-ways, used for the treatment of a range of aquatic pollutants, and their performance is dependent on the rate at which the algae can both assimilate nutrients from the ...
Sutherland, DL, Ralph, PJ, Burke, J
core   +1 more source

Nutrient removal, performance of growth and yield of faba bean (Vicia faba L.)

, 2010
A study on 12 faba bean genotypes was conducted for 2 years to evaluate its growth, nutrient removal, yield and yield components. The genotypes were KITIKI-2003, ERESEN-87, FİLİZ-99, SEVİL, SAKIZ, 95 ETA 225, 95 ETA 249, 95 ETA 276, 97 ETA 718, 97 ETA 727, 98 ETA 296 and 98 ETA 329.
Daur, Ihsanullah, Sepetoglu, Hasan, Marwat, Khan Bahadar, Geverek, Mithat Nuri   +3 more
openaire   +4 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Production of Carbohydrate-Rich Chlorella sp. Biomass Using Clarified Aquaponics Effluent for Bioethanol Feedstock Applications

Biomass
The integration of microalgal cultivation with wastewater streams offers a promising pathway to enhance resource efficiency within circular bioeconomy frameworks.
Charith Akalanka Dodangodage, Geethaka Nethsara Gamage, Lakru C. Mallawa, Jagath C. Kasturiarachchi, Kavini Vindya Fernando, Ranoda Hasandee Halwatura, Thilini A. Perera, Sanjitha Dilan Rajapakshe, Sayuri S. Niyangoda, Rangika Umesh Halwatura   +9 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Waikato peat lakes sediment nutrient removal scoping exercise

, 2008
This report was commissioned by Environment Waikato to examine the available methods for internal (bottom sediment) nutrient removal and their suitability for application in the Waikato peat lakes.
Faithfull, Carolyn L., Burger, David F., Duggan, Ian C., Hamilton, David P.   +3 more
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The effect of alternative detergent builders on the nutrient removal activated sludge sewage treatment process

, 1993
Includes bibliography.Phosphate is an essential nutrient for photosynthetic plant growth. However if over-supplied in a water body, it leads to excessive algal growth, a condition is termed eutrophication.
Kaschula, Wendy A
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source