Results 81 to 90 of about 384,987 (307)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Partial substitution of nitrogen fertilizer by Chinese milk vetch with different improvement measures achieves a win-win for rice productivity and environmental benefits

Frontiers in Plant Science
IntroductionGreen manuring has been proven to be a sustainable strategy for enhancing paddy soil fertility and reducing chemical fertilizer input. However, the anaerobic decomposition of green manure in flooded soils leads to substantial increase in ...
Shang Han, Shang Han, Rongyan Bu, Guopeng Zhou, Shan Tang, Hui Wang, Min Li, Wenlong Cheng, Ji Wu, Hongjian Gao   +9 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Impact of Phosphorus Fertilization on Leaching, Accumulation, and Microbial Cycling in New Apple Orchards

Agronomy
Field experiments spanning five years were conducted to convert barren mountainous land into apple orchards, testing five phosphorus (P) fertilization schemes: no inorganic P (NP0K), superphosphate (FP), water-soluble inorganic P (WSF), superphosphate ...
Yuwen Shen, Haitao Lin, Rui Xue, Yanan Ma, Yan Song   +4 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Microbial-mediated structural changes in humic acid increase phosphorus availability in the fertosphere

Geoderma
It is widely accepted that humic acid-enhanced phosphate fertilizers (HAEP) improve crop yield and phosphorus (P) use efficiency, largely because the carboxyl-rich structure of humic acid (HA) reduces P fixation and enhances soil P availability. However,
Yanna Luo, Yunbo Niu, Wentao Pan, Lei Shi, Yingqiang Zhang, Xinxin Ye, Qizhong Xiong, Bingqiang Zhao, Jianyuan Jing   +8 more
doaj   +1 more source

Effects of organic plant oils and role of oxidation on nutrient utilization in juvenile rainbow trout (Oncorhynchus mykiss) [PDF]

, 2012
The study compared the effect of four either fresh or force oxidized organic plant oils in diets for juvenile rainbow trout (Oncorhynchus mykiss) in which 47% of conventional LT fish meal protein was substituted by a mixture of 3 organic plant protein ...
A. Jokumsen, Bell, Bligh, Bransden, Børsting, C. Jacobsen, Caballero, Dalsgaard, Fountoulaki, Geurden, Geurden, I. Lund, J. Dalsgaard, J. Holm, J.H. Hansen, Jobling, Kaitaranta, Kasumyan, Kolar, Koshio, Laohabanjong, Lund, Lund, Lutterodt, Menoyo, Mente, Ng, Peng, Petersen, Petterson, Pickova, Ping, Shahidi, Shantha, Singh, Sun-Waterhouse, Takeda, Tyl   +37 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Controlled-Release Nitrogen Fertilizer Enhances Saline–Alkali Soil Organic Carbon by Activating Straw Decomposition Agents

Agronomy
Soil organic carbon (SOC) represents a crucial factor in agricultural production, and its accumulation is influenced by soil microbial community and microbial metabolism.
Rui Xue, Zhengrui Wang, Qing Liu, Kun Song, Shanda Yuan, Mei Wang, Yuwen Shen, Guangqing Ji, Haitao Lin   +8 more
doaj   +1 more source