Results 71 to 80 of about 2,469,745 (360)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

p53 protein degradation redefines the initiation mechanisms and drives transitional mutations in colorectal cancer

Nature Communications
Incidence of colorectal cancer (CRC) is increasing likely due to different mechanisms driving initiation and progression. The initial model proposed by Fearon and Vogelstein posits it as a multi-hit neoplasia, originating from adenomatous-polyps induced ...
Irene Herranz-Montoya, Mariana Angulo-Aguado, Cristian Perna, Sladjana Zagorac, Luis García-Jimeno, Solip Park, Nabil Djouder   +6 more
doaj   +1 more source

Biogeochemical nutrient cycles and nutrient management strategies [PDF]

Hydrobiologia, 1999
Nutrient loading by riverine input into estuarine systems has increased by 6–50 times for the N load from pristine conditions to present, whereas a 18–180 times increase has been observed in the P load. Reductions in the ratio of N to P delivery has also occurred with time.
openaire   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Ideotyping integrated aquaculture systems to balance soil nutrients. [PDF]

, 2011
Due to growing land scarcity and lack of nutrient inputs, African farmers switched from shifting cultivation to continuous cropping and extended crop area by bringing fragile lands such as river banks and hill slopes into production.
Mora Vallejo, A.P., Muendo, P.N., Stoorvogel, J.J., Verdegem, M.C.J., Verreth, J.A.J.   +4 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A novel hepatocyte ketone production assay to help the selection of nutrients for the ketogenic diet treatment of epilepsy

Scientific Reports
The classic ketogenic diet is an effective treatment option for drug-resistant epilepsy, but its high fat content challenges patient compliance. Optimizing liver ketone production guided by a method comparing substrates for their ketogenic potential may ...
Hester Meeusen, Alessia Romagnolo, Sophie A. C. Holsink, Thijs J. M. van den Broek, Ardy van Helvoort, Jan A. Gorter, Erwin A. van Vliet, J. Martin Verkuyl, Jose P. Silva, Eleonora Aronica   +9 more
doaj   +1 more source

Cold exposure reinstates NAD+ levels and attenuates hepatocellular carcinoma

Cell Stress
Cold exposure has been historically used for medicinal purposes, but its benefits and associated mechanisms in mammalian organisms still remain unclear.
Tatiana P Grazioso, Maria del Mar Rigual, Cristian Perna, Eduardo J Caleiras, Nabil Djouder   +4 more
doaj   +1 more source

Optimizing nitrogen utilization by ecological recycling agriculture (ERA) [PDF]

, 2013
The main purpose of agriculture is food production. There are always limited resources available for food production, thus the resource efficiency is always the key issue.
Seuri, Pentti
core  

Simultaneous ammonium and phosphate recovery and stabilization from urban sewage sludge anaerobic digestates using reactive sorbents [PDF]

, 2018
The use of low-cost inorganic sorbents as a new sustainable strategy to enhance the valorization of nutrients (N-P-K), from the urban water cycle (e.g., side streams from sewage sludge anaerobic digestion), in agriculture applications is presented.
Batis, Narjes, Cortina Pallás, José Luís, Dosta, Joan, Hermassi, Mehrez, Licon Bernal, Edxon Eduardo, Moreno Palmerola, Natàlia, Querol Carceller, Xavier, Valderrama Angel, César Alberto   +7 more
core   +2 more sources