Results 41 to 50 of about 1,105,943 (300)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

The effect of nutrition education on nutrition‐related health outcomes of Aboriginal and Torres Strait Islander people: a systematic review

Australian and New Zealand Journal of Public Health, 2016
Objective: To determine the effectiveness of nutrition education on improving nutrition‐related health outcomes in Aboriginal and Torres Strait Islander people.
Laura Schembri, Johannah Curran, Lyndal Collins, Marta Pelinovskaia, Hayley Bell, Christina Richardson, Claire Palermo   +6 more
doaj   +1 more source

Evaluating a nutrition education component of the Ka Mau Te WEHI program : a thesis presented in the partial fulfilment of the requirements for the degree of Masters of Science in Nutrition and Dietetics at Massey University, Albany, New Zealand [PDF]

, 2017
Background: New Zealand has high rates (32%) of obesity amongst the adult population; Māori (50.2%) and Pacific (68.7%) populations are most affected. Lifestyle interventions are effective in achieving weight loss, but are often expensive, whilst group ...
Gibson, Greer
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Nutrition in medical education: reflections from an initiative at the University of Cambridge

Journal of Multidisciplinary Healthcare, 2014
Lauren Ball,1 Jennifer Crowley,2 Celia Laur,3 Minha Rajput-Ray,3 Stephen Gillam,4 Sumantra Ray3 1Nutrition and Dietetics, School of Allied Health Sciences, Centre for Health Practice Innovation, Griffith University, Queensland, Brisbane, Australia ...
Ball L, Crowley J, Laur C, Rajput-Ray M, Gillam S, Ray S   +5 more
doaj  

Nutrition and Exercise Resources for Clinton County [PDF]

, 2017
The obesity epidemic is a nation wide problem that has increased prevalence in Clinton County, NY when compared to the surrounding areas. Obesity leads to many co-morbid health conditions and is associated with a large increase in health care spending ...
Wood, Paige M
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

The Effect of Sociodemographic and Anthropometric Variables on Nutritional Knowledge and Nutrition Literacy

Foods
Nutrition literacy, which is one of the important components of health literacy, includes basic nutritional information and understanding, interpreting and having the ability to make healthy decisions on nutrition-related issues. This study aims to dwell
Nevin Sanlier, Funda Kocaay, Sule Kocabas, Pinar Ayyildiz   +3 more
doaj   +1 more source

Nutrition Education in Medical Schools: What do Medical Students Think?

Journal of Medical Education and Curricular Development, 2023
Objective To examine medical students’ perceptions of the nutrition education received and their ability to apply that knowledge in clinical settings.
Shanika Boyce, Huan V Dong, Alma Guerrero, Christine Thang, Cambria Garell, Catherine Carpenter, Wendelin Slusser   +6 more
doaj   +1 more source