Results 31 to 40 of about 413,630 (215)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Thyroid Ultrasound Appropriateness Identification Through Natural Language Processing of Electronic Health Records

Mayo Clinic Proceedings: Digital Health
Objective: To address thyroid cancer overdiagnosis, we aim to develop a natural language processing (NLP) algorithm to determine the appropriateness of thyroid ultrasounds (TUS).
Cristian Soto Jacome, MD, Danny Segura Torres, MD, Jungwei W. Fan, PhD, Ricardo Loor-Torres, MD, Mayra Duran, MD, Misk Al Zahidy, MS, Esteban Cabezas, MD, Mariana Borras-Osorio, MD, David Toro-Tobon, MD, Yuqi Wu, PhD, Yonghui Wu, PhD, Naykky Singh Ospina, MD, MS, Juan P. Brito, MD, MS   +12 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Identifying biologically implausible values in big longitudinal data: an example applied to child growth data from the Brazilian food and nutrition surveillance system

BMC Medical Research Methodology
Background Several strategies for identifying biologically implausible values in longitudinal anthropometric data have recently been proposed, but the suitability of these strategies for large population datasets needs to be better understood. This study
Juliana Freitas de Mello e Silva, Natanael de Jesus Silva, Thaís Rangel Bousquet Carrilho, Elizabete de Jesus Pinto, Aline Santos Rocha, Jéssica Pedroso, Sara Araújo Silva, Ana Maria Spaniol, Rafaella da Costa Santin de Andrade, Gisele Ane Bortolini, Enny Paixão, Gilberto Kac, Rita de Cássia Ribeiro-Silva, Maurício L. Barreto   +13 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Diet, nutrition, and climate: historical and contemporary connections

Frontiers in Nutrition
This paper reviews the past global nutrition efforts, particularly those led by the Global Alliance for Improved Nutrition (GAIN), at the critical intersection of nutrition and climate change.
Kathrin M. Demmler, M. Ann Tutwiler
doaj   +1 more source

Nutrition knowledge of people with eating disorders

Roczniki Panstwowego Zakladu Higieny, 2019
Background: Eating disorders are an increasingly common health problem that is a major therapeutic challenge. For many years, the basic form of therapy used to be psychiatric and psychotherapeutic treatment, but now it is postulated that the ...
Beata Całyniuk, Michał Górski, Jagoda Garbicz, Elżbieta Grochowska-Niedworok   +3 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Humanizing care in the ICU: how system pressures shape interacting patterns of hurry, blur, burden, and cruelty

Frontiers in Health Services
BackgroundIntensive care units are high-acuity environments characterized by time pressure, medical complexity, and organizational demands. These conditions may influence clinicians’ ability to provide patient-centered care and contribute to forms of ...
Misk Al Zahidy, Ana Gabriela Claros, Katerina Mulanovich, Mohamed A. Mahmoud, Michael R. Gionfriddo, Maria Jose Lizarazo, Maria Mateo Chavez, Ahmed Sayed Ahmed, Yue Dong, Ognjen Gajic, Victor M. Montori, Sumera Ahmad   +11 more
doaj   +1 more source