Results 41 to 50 of about 83,171 (264)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Factors associated with overweight and obesity in Mexican school-age children: results from the National Nutrition Survey 1999

Salud Pública de México, 2003
OBJECTIVE: The objective of the study was to measure the prevalence of overweight and obesity in Mexican school-age children (5-11 years) in the National Nutrition Survey 1999 (NNS-1999). MATERIAL AND METHODS: Overweight and obesity (defined as an excess
Hernández Bernardo, Cuevas-Nasu Lucía, Shamah-Levy Teresa, Monterrubio Eric A, Ramírez-Silva Claudia Ivonne, García-Feregrino Raquel, Rivera Juan A, Sepúlveda-Amor Jaime   +7 more
doaj  

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Factors associated with overweight and obesity in Mexican school-age children: results from the National Nutrition Survey 1999 Factores asociados con sobrepeso y obesidad en niños mexicanos de edad escolar: resultados de la Encuesta Nacional de Nutrición, 1999

Salud Pública de México, 2003
OBJECTIVE: The objective of the study was to measure the prevalence of overweight and obesity in Mexican school-age children (5-11 years) in the National Nutrition Survey 1999 (NNS-1999). MATERIAL AND METHODS: Overweight and obesity (defined as an excess
Bernardo Hernández, Lucía Cuevas-Nasu, Teresa Shamah-Levy, Eric A Monterrubio, Claudia Ivonne Ramírez-Silva, Raquel García-Feregrino, Juan A Rivera, Jaime Sepúlveda-Amor   +7 more
doaj  

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Concentraciones de yodo en orina y en sal de consumo en mujeres entre 12 a 49 años del Perú

Revista Peruana de Medicina Experimental y Salud Pública
Objetivos. Determinar las concentraciones de yodo en orina y sal de consumo en mujeres entre 12 a 49 años en Perú. Materiales y métodos. Se realizó un estudio observacional y transversal.
Carolina Tarqui-Mamani, José Sánchez-Abanto, Doris Alvarez-Dongo, Teresa Jordán-Lechuga, Inés Fernández-Tinco   +4 more
doaj   +2 more sources

Consumo de energía y nutrimentos en mujeres mexicanas en edad reproductiva Energy and nutrient intake in mexican women of reproductive age

Salud Pública de México, 1998
Objetivo. Analizar el consumo de energía y nutrimentos de mujeres mexicanas de 12 a 49 años de edad. Material y métodos. La información dietética se obtuvo por recordatorio de 24 horas en 9 101 mujeres participantes en la Encuesta Nacional de Nutrición ...
MARIO FLORES, HUGO MELGAR, CECILIA CORTÉS, MARTA RIVERA, JUAN RIVERA, JAIME SEPÚLVEDA   +5 more
doaj  

Comparing hemoglobin distributions between population-based surveys matched by country and time

BMC Public Health, 2020
Background Valid measurement of hemoglobin is important for tracking and targeting interventions. This study compares hemoglobin distributions between surveys matched by country and time from The Demographic and Health Survey (DHS) Program and the ...
Daniel J. Hruschka, Anne M. Williams, Zuguo Mei, Eva Leidman, Parminder S. Suchdev, Melissa F. Young, Sorrel Namaste   +6 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source