Results 61 to 70 of about 35,176 (268)

Grazing effects on the nutritive value of dominant species in steppe grasslands of northern China

BMC Ecology, 2018
Background Forage nutritive value plays an important role in livestock nutrition and maintaining sustainable grassland ecosystems, and grazing management can affect the quality of forage.
Xiajie Zhai, Yingjun Zhang, Kun Wang, Qian Chen, Shuiyan Li, Ding Huang   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

THE NUTRITIVE VALUE OF BOILED MILK [PDF]

Archives of Pediatrics & Adolescent Medicine, 1916
The experimental work involved in this report is the result of an attempt to determine the comparative nutritive efficiency of milk heated to different temperatures. There is considerable evidence in the literature to the effect that scurvy among infants may be caused by feeding cooked milk exclusively; in fact, this notion is so prevalent that many ...
openaire   +2 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Nutritive value of perennial pastures along an elevation gradient in tropical conditions

Frontiers in Sustainable Food Systems
IntroductionThe nutritive value of forages is one of the main drivers of productivity for livestock. In many tropical regions, same grass species occur at different elevations, but few studies have evaluated nutritive value changes within elevation ...
Luis Villalobos, Claudia Arndt, Rein van der Hoek, Andre M. Mazzetto, Dave Chadwick   +4 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Estimation of genetic parameters and selection of Brachiaria humidicola progenies using a selection index

Crop Breeding and Applied Biotechnology, 2012
The objectives of this study were to estimate genetic parameters for agronomic and nutritive value traits for leaves and stems of Brachiaria humidicola progenies and to compare the selection using an additive index considering the agronomic traits alone ...
Ulisses José de Figueiredo, José Airton Rodrigues Nunes, Cacilda Borges do Valle   +2 more
doaj  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Chemical characterization of green grain before and after thermal processing in biofortified cowpea cultivars

Revista Ciência Agronômica
The cowpea (Vigna unguiculata (L.) Walp.) is one of the most widely consumed legumes in the North and Northeast of Brazil, representing an important source of protein, energy, fibre and minerals, in addition to generating employment and income.
Natália Quaresma Costa Melo, Regilda Saraiva dos Reis Moreira-Araújo, Marcos Antônio da Mota Araújo, Maurisrael de Moura Rocha   +3 more
doaj   +1 more source