Results 151 to 160 of about 2,530 (193)

Biogenesis and function of circular RNAs and their implications in the Down syndrome brain. [PDF]

Front Genet
Zainal Abidin S, Razali NN, Cheah PS, Ling KH.   +3 more
europepmc   +1 more source

One RNA-binding protein, many decisions: integrating the transcript life cycle into neuronal regulation. [PDF]

Front Mol Neurosci
Doxakis E, Xue YC, Savulescu AF.
europepmc   +1 more source

The functions of herpesvirus shuttling proteins in the virus lifecycle. [PDF]

Front Microbiol
Cao H, Wang M, Cheng A, Tian B, Yang Q, Ou X, Sun D, He Y, Wu Z, Zhao X, Wu Y, Zhang S, Huang J, Yu Y, Zhang L, Chen S, Liu M, Zhu D, Jia R.   +18 more
europepmc   +1 more source

TREX-2-ORC Complex of D. melanogaster Participates in Nuclear Export of Histone mRNA. [PDF]

Dokl Biochem Biophys
Kurshakova MM, Yakusheva YA, Georgieva SG.   +2 more
europepmc   +1 more source

TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export [PDF]

Nature Communications, 2012
The metazoan TREX complex is recruited to mRNA during nuclear RNA processing and functions in exporting mRNA to the cytoplasm. Nxf1 is an mRNA export receptor, which binds processed mRNA and transports it through the nuclear pore complex. At present, the
Nicolas Viphakone, Guillaume M Hautbergue, Stuart A Wilson   +2 more
exaly   +8 more sources

Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1

Molecular Biology of the Cell, 2011
In human cells, the mRNA export factor NXF1 resides in the nucleoplasm and at nuclear pore complexes. Karyopherin β2 or transportin recognizes a proline–tyrosine nuclear localization signal (PY-NLS) in the N-terminal tail of NXF1 and imports it into the
Beatriz M A Fontoura, Yuh Min Chook
exaly   +4 more sources

Germline heterozygous mutations in Nxf1 perturb RNA metabolism and trigger thrombocytopenia and lymphopenia in mice [PDF]

Blood Advances, 2020
In eukaryotic cells, messenger RNA (mRNA) molecules are exported from the nucleus to the cytoplasm, where they are translated. The highly conserved protein nuclear RNA export factor1 (Nxf1) is an important mediator of this process.
Charity Wai Man Law, Gordon K Smyth, Hoang Linh Ngo   +2 more
exaly   +6 more sources

Evidence for Viral mRNA Export from Ebola Virus Inclusion Bodies by the Nuclear RNA Export Factor NXF1.

Journal of Virology, 2022
Many negative-sense RNA viruses, including the highly pathogenic Ebola virus (EBOV), use cytoplasmic inclusion bodies (IBs) for viral RNA synthesis. However, it remains unclear how viral mRNAs are exported from these IBs for subsequent translation.
Allison Groseth, Bianca S Bodmer, Lisa Wendt   +2 more
exaly   +2 more sources

The mRNA Export Receptor NXF1 Coordinates Transcriptional Dynamics, Alternative Polyadenylation, and mRNA Export [PDF]

Molecular Cell, 2019
Alternative polyadenylation (APA) produces mRNA isoforms with different 3' UTR lengths. Previous studies indicated that 3' end processing and mRNA export are intertwined in gene regulation. Here, we show that mRNA export factors generally facilitate usage of distal cleavage and polyadenylation sites (PASs), leading to long 3' UTR isoform expression. By
Bin Tian, Hong Cheng, Ruijia Wang
exaly   +3 more sources