Results 161 to 170 of about 2,530 (193)

Nuclear Export of mRNA by TAP/NXF1 Requires Two Nucleoporin-Binding Sites but Not p15 [PDF]

Molecular and Cellular Biology, 2002
Metazoan NXF1/p15 heterodimers promote export of bulk mRNA through nuclear pore complexes (NPC). NXF1 interacts with the NPC via two distinct structural domains, the UBA-like domain and the NTF2-like scaffold, which results from the heterodimerization of the NTF2-like domain of NXF1 with p15.
Elisa Izaurralde, Isabelle C Braun
exaly   +3 more sources

RanBP2/Nup358 Provides a Major Binding Site for NXF1-p15 Dimers at the Nuclear Pore Complex and Functions in Nuclear mRNA Export

Molecular and Cellular Biology, 2004
Metazoan NXF1-p15 heterodimers promote the nuclear export of bulk mRNA across nuclear pore complexes (NPCs). In vitro, NXF1-p15 forms a stable complex with the nucleoporin RanBP2/Nup358, a component of the cytoplasmic filaments of the NPC, suggesting a ...
Jan Ellenberg, Elisa Izaurralde, Peer Bork   +2 more
exaly   +2 more sources

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URH49 exports mRNA by remodeling complex formation and mediating the NXF1-dependent pathway

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2020
The TREX complex integrates information from nuclear mRNA processing events to ensure the timely export of mRNA to the cytoplasm. In humans, UAP56 and its paralog URH49 form distinct complexes, the TREX complex and the AREX complex, respectively, which cooperatively regulate the expression of a specific set of mRNA species on a genome wide scale.
Ken-Ichi, Fujita, Tomohiro, Yamazaki, Kotaro, Harada, Shigeto, Seno, Hideo, Matsuda, Seiji, Masuda   +5 more
openaire   +2 more sources

Structure of the C-terminal FG-nucleoporin binding domain of Tap/NXF1

Nature Structural Biology, 2002
The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for nuclear export of mRNA. Tap has a modular structure, and its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate nuclear shuttling.
Richard P, Grant, Ed, Hurt, David, Neuhaus, Murray, Stewart   +3 more
openaire   +2 more sources

Allostery and inter-domain dynamics in NXF1: An insight into viral CTE-RNA binding

International Journal of Biological Macromolecules
Nucleocytoplasmic export of mRNA is a fundamental process in eukaryotic cells, facilitating the transportation of mRNA transcripts from nucleus to cytoplasm. Central to this pathway is Nuclear Export Factor 1 (NXF1), a key RNA binding protein (RBP) mediating mRNA export through the Nuclear Pore Complex (NPC).
Ranjit Prasad Bahadur
exaly   +3 more sources

Alternative transcripts expressed by small bristles, the Drosophila melanogaster nxf1 gene

Gene, 2010
The tissue-specific accumulation of small bristles (Dm nxf1) transcripts at different developmental stages of Drosophila melanogaster was analyzed by Northern blots and RT PCR. We identified four distinct transcripts: ubiquitous (3.5kb); ovary and early embryo specific (3.3kb); testis specific (1.9kb and 2.8kb) and nervous system specific (5.1kb).
Natalia, Ivankova, Irina, Tretyakova, George T, Lyozin, Elina, Avanesyan, Andrei, Zolotukhin, Olga G, Zatsepina, Michael B, Evgen'ev, Ludmila A, Mamon   +7 more
openaire   +2 more sources

Imaging within single NPCs reveals NXF1’s role in mRNA export on the cytoplasmic side of the pore [PDF]

Journal of Cell Biology, 2019
Translocation of mRNA through the nuclear pore complex (NPC) requires interactions with different NPC regions. To determine the interactions that are crucial for effective mRNA export in living cells, we examined mRNA export within individual pores by applying various types of mRNA export blocks that stalled mRNPs at different stages of transition ...
Avi Jacob, Yaron Shav-Tal, Yuval Garini
exaly   +3 more sources

KRAB Zinc Finger protein Znf684 interacts with Nxf1 to regulate mRNA export

2021
Abstract Cys2His2 (C2H2) type zinc finger (ZnF) proteins constitute a large class of proteins that are generally considered to be DNA-binding transcription factors. Using affinity purification followed by mass spectrometry, as well as reciprocal co-immunoprecipitation experiments, we determined that the C2H2-ZnF ...
Alexandra Nitoiu, Syed Nabeel-Shah, Shaghayegh Farhangmehr, Shuye Pu, Ulrich Braunschweig, Benjamin J. Blencowe, Jack F. Greenblatt   +6 more
openaire   +1 more source

Interaction of CDK12 with NXF1 is a new node for the linking mechanism between transcription and transportation of mRNA

Biochemical and Biophysical Research Communications
The transcription and transportation of mRNA are coupled processes; however, the mechanisms linking these processes remain unclear. Additionally, the significance of this connection in cancer drug development is poorly understood. To address these issues, we investigated the role of CDK12 kinase, which regulates RNA transcription through the ...
Yasumichi Inoue, Kenichiro Shimokawa, Hiroshi Tauchi   +2 more
exaly   +3 more sources

The role of sbr/Dm nxf1 gene in syncytial development in Drosophila melanogaster

Cell and Tissue Biology, 2015
Syncytial development is a property of early embryogenesis and spermatogenesis in Drosophila melanogaster. All elements of syncytium are linked in a common cytoskeletal network, which provides equal conditions and synchronous divisions of each nucleus. The cytoskeleton is necessary for the formation and function of the spindle.
E. V. Golubkova, A. A. Atsapkina, L. A. Mamon   +2 more
openaire   +1 more source