Results 61 to 70 of about 14,068 (233)

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source

O-GlcNAcylation in ischemic diseases

Frontiers in Pharmacology
Protein glycosylation is an extensively studied field, with the most studied forms being oxygen or nitrogen-linked N-acetylglucosamine (O-GlcNAc or N-GlcNAc) glycosylation. Particular residues on proteins are targeted by O-GlcNAcylation, which is among the most intricate post-translational modifications.
Rui-Rui Shi, Tian-Qi He, Tian-Qi He, Meng-Si Lin, Jian Xu, Jian Xu, Jin-Hua Gu, Jin-Hua Gu, Hui Xu   +8 more
openaire   +3 more sources

FBXO31-mediated ubiquitination of OGT maintains O-GlcNAcylation homeostasis to restrain endometrial malignancy

Nature Communications
Protein O-GlcNAcylation is a post-translational modification coupled to cellular metabolic plasticity. Aberrant O-GlcNAcylation has been observed in many cancers including endometrial cancer (EC), a common malignancy in women.
Na Zhang, Yang Meng, Song Mao, Huiling Ni, Canhua Huang, Licong Shen, Kun Fu, Lu Lv, Chunhong Yu, Piyanat Meekrathok, Chunmei Kuang, Fang Chen, Yu Zhang, Kai Yuan   +13 more
doaj   +1 more source

Roles of O-GlcNAcylation in Mitochondrial Homeostasis and Cardiovascular Diseases

Antioxidants
Protein posttranslational modifications are important factors that mediate the fine regulation of signaling molecules. O-linked β-N-acetylglucosamine-modification (O-GlcNAcylation) is a monosaccharide modification on N-acetylglucosamine linked to the ...
Zhen Qiu, Jiahui Cui, Qin Huang, Biao Qi, Zhongyuan Xia   +4 more
doaj   +1 more source

O-GlcNacylation Links TxNIP to Inflammasome Activation in Pancreatic β Cells

Frontiers in Endocrinology, 2019
Thioredoxin interacting protein (TxNIP), which strongly responds to glucose, has emerged as a central mediator of glucotoxicity in pancreatic β cells.
Gaelle Filhoulaud, Gaelle Filhoulaud, Gaelle Filhoulaud, Fadila Benhamed, Fadila Benhamed, Fadila Benhamed, Patrick Pagesy, Patrick Pagesy, Patrick Pagesy, Caroline Bonner, Caroline Bonner, Yann Fardini, Yann Fardini, Yann Fardini, Anissa Ilias, Anissa Ilias, Jamileh Movassat, Jamileh Movassat, Anne-Françoise Burnol, Anne-Françoise Burnol, Anne-Françoise Burnol, Sandra Guilmeau, Sandra Guilmeau, Sandra Guilmeau, Julie Kerr-Conte, François Pattou, François Pattou, Tarik Issad, Tarik Issad, Tarik Issad, Catherine Postic, Catherine Postic, Catherine Postic   +32 more
doaj   +1 more source

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy [PDF]

, 2016
Sustained glucose and glutamine transport are essential for activated T lymphocytes to support ATP and macromolecule biosynthesis. We now show that glutamine and glucose also fuel an indispensible dynamic regulation of intracellular protein O ...
A Boudil, A Golks, A Suzuki, A Wolfer, AJ Marko, AL Doedens, AN Macintyre, AP Kelly, C-H Chang, C-Y Huang, Daan M F van Aalten, DC Turnock, DK Finlay, Doreen A Cantrell, EL Carr, EL Pearce, FV Rao, G Balciunaite, GC Preston, GW Hart, GW Hart, HC Dorfmueller, HJ Hinton, J Rolf, J Zhang, J Zhong, Katarzyna M Grzes, KP Kearse, Linda V Sinclair, LJ Beverly, LV Sinclair, M Ciofani, M Ciofani, M Dose, M Dose, M Nakaya, Mahima Swamy, MP Mycko, MR Bond, N O'Donnell, NJ MacIver, P Ramakrishnan, P-C Ho, R Shafi, R Wang, Sebastian Damerow, Shalini Pathak, TJ Hagenbeek, TJ Hagenbeek, TM Gloster, TM Schmitt, TY Chou, U Koch, W Liao, Z Wang   +54 more
core   +3 more sources

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

The role of O‐GlcNAcylation in immunity against infections [PDF]

Immunology, 2020
SummaryMounting an effective immune response is crucial for the host to protect itself against invading pathogens. It is now well appreciated that reprogramming of core metabolic pathways in immune cells is a key requirement for their activation and function during infections.
Quik, M., Hokke, C.H., Everts, B.
openaire   +3 more sources

Production of Glycopeptide Derivatives for Exploring Substrate Specificity of Human OGA Toward Sugar Moiety. [PDF]

, 2018
O-GlcNAcase (OGA) is the only enzyme responsible for removing N-acetyl glucosamine (GlcNAc) attached to serine and threonine residues on proteins. This enzyme plays a key role in O-GlcNAc metabolism.
Chen, Xi, Chen, Yi, Guo, Jianshuang, Li, Jing, Li, Shanshan, Li, Yanhong, Wang, Jiajia, Wang, Peng George, Wen, Liuqing, Zang, Lanlan, Zhang, Jiabin, Zhu, Hailiang   +11 more
core  

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source