Results 71 to 80 of about 10,612,241 (292)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Multi-UE 5G RAN Measurements: A Gamut of Architectural Options

IEEE Access
The Radio Access Network (RAN) of Fifth Generation (5G) communication systems critically influences the overall performance and cost of a 5G system.
Andreas Ingo Grohmann, Mauri Seidel, Sebastian A. W. Itting, Ray-Guang Cheng, Martin Reisslein, Frank H. P. Fitzek   +5 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

TACIT: Trustworthy Arbitration Through Calibrated Inference Tracking for rApp Conflict Resolution in O-RAN

IEEE Access
Open Radio Access Network (O-RAN) deployments face a coordination challenge when multiple radio applications (rApps) concurrently propose conflicting parameter changes.
Joss Armstrong, Sheila Fallon, Enda Fallon   +2 more
doaj   +1 more source

Detection of UE Metric Data Poisoning in O-RAN: Automated Risk Analysis and Resilience

The implementation of open radio access network (O-RAN) architecture brings with it new security challenges, owing to the use of machine learning (ML) methods on the near-real-time radio access network (RAN) intelligent controller (Near-RT RIC) and non ...
Duong, Trung Q., Sharma, Vishal, Canberk, Berk, Megarry, Mark   +3 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Energy Consumption of Machine Learning Enhanced Open RAN: A Comprehensive Review

IEEE Access
The Open Radio Access Network (RAN) emerges as a revolutionary architecture promising unprecedented levels of openness, flexibility, and intelligence within radio access networks. Central to this innovation is the integration of Machine Learning (ML) and
Xuanyu Liang, Qiao Wang, Ahmed Al-Tahmeesschi, Swarna B. Chetty, David Grace, Hamed Ahmadi   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

User Classification and Traffic Steering in O-RAN

IEEE Open Journal of the Communications Society
The O-RAN architectural framework enables the application of AI/ML techniques for traffic steering and load balancing. Indeed, an effective steering technique is crucial to avoiding ping-pong and radio link failure. Limited observability and network complexity make it challenging to understand individual user needs.
Ntassah, Rawlings, Dell'area, Gian Michele, Granelli, Fabrizio   +2 more
openaire   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source