Results 71 to 80 of about 15,473,053 (283)

Challenges of O-RAN Integration with existing RAN Architecture [PDF]

Radio access networks (RAN) have undergone significant evolution across generations of mobile networks. This evolution has been driven by the need to adapt to different types of communication services and cater to the diverse needs of end-users.
Lakshman, Arun
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Energy Consumption of Machine Learning Enhanced Open RAN: A Comprehensive Review

IEEE Access
The Open Radio Access Network (RAN) emerges as a revolutionary architecture promising unprecedented levels of openness, flexibility, and intelligence within radio access networks. Central to this innovation is the integration of Machine Learning (ML) and
Xuanyu Liang, Qiao Wang, Ahmed Al-Tahmeesschi, Swarna B. Chetty, David Grace, Hamed Ahmadi   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

User Classification and Traffic Steering in O-RAN

IEEE Open Journal of the Communications Society
The O-RAN architectural framework enables the application of AI/ML techniques for traffic steering and load balancing. Indeed, an effective steering technique is crucial to avoiding ping-pong and radio link failure. Limited observability and network complexity make it challenging to understand individual user needs.
Ntassah, Rawlings, Dell'area, Gian Michele, Granelli, Fabrizio   +2 more
openaire   +4 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

RRC Signaling Storm Detection in O-RAN

2025 IEEE Symposium on Computers and Communications (ISCC)
The Open Radio Access Network (O-RAN) marks a significant shift in the mobile network industry. By transforming a traditionally vertically integrated architecture into an open, data-driven one, O-RAN promises to enhance operational flexibility and drive innovation.
Dang Kien Nguyen, Rim El Malki, Filippo Rebecchi   +2 more
openaire   +3 more sources

Security Threats to xApps Access Control and E2 Interface in O-RAN

IEEE Open Journal of the Communications Society
Open Radio Access Networks (O-RANs) represent a novel wireless access network architecture that decomposes traditional RAN functions and makes them openly accessible.
Cheng-Feng Hung, You-Run Chen, Chi-Heng Tseng, Shin-Ming Cheng   +3 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

A Survey and an Analysis of Conflict Management in O-RAN

IEEE Open Journal of the Communications Society
The emergence of the Open Radio Access Network (O-RAN) introduces unprecedented flexibility, programmability, and multi-vendor interoperability into cellular systems.
Francielly De Souza Almeida, Fuad M. Abinader, Bruno Silvestre, Alexandre Huff, Daniel Ventura, Sand L. Correa   +5 more
doaj   +1 more source