Results 71 to 80 of about 105,603 (259)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Proactive AI-and-RAN Workload Orchestration in O-RAN Architectures for 6G Networks

IEEE Open Journal of the Communications Society
The vision of AI-RAN convergence, as advocated by the AI-RAN Alliance, aims to unlock a unified 6G platform capable of seamlessly supporting AI and RAN workloads over shared infrastructure.
Syed Danial Ali Shah, Maryam Hafeez, Abdelaziz Salama, Syed Ali Raza Zaidi   +3 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Detecting Out-of-Order Control Messages in O-RAN: Dataset, Benchmarks, and Early-Warning Models

IEEE Open Journal of the Communications Society
The Open Radio Access Network (O-RAN) architecture introduces openness, programmability, and multi-vendor xApp innovation through the Near-Real-Time RAN Intelligent Controller (Near-RT RIC).
Hams Gelban, Rouaa Naim, Ahmed Badawy
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

DRL-Based RAN Slicing With Efficient Inter-Slice Isolation in Tactical Wireless Networks

IEEE Open Journal of Vehicular Technology
The next generation of tactical networks (TNs) is poised to further leverage the key enablers of 5G and beyond 5G (B5G) technology, such as radio access network (RAN) slicing and the open RAN (O-RAN) paradigm, to unlock new architectural options for ...
Abderrahime Filali, Diala Naboulsi, Georges Kaddoum   +2 more
doaj   +1 more source

Toward Modular and Flexible Open RAN Implementations in 6G Networks: Traffic Steering Use Case and O-RAN xApps. [PDF]

Sensors (Basel), 2021
Dryjański M, Kułacz Ł, Kliks A.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

O-RAN-Enabled Adaptive Relaying for Robust V2X Communication in Urban NLOS Scenarios

IEEE Access
The Open Radio Access Network (O-RAN) introduces programmability and intelligence into wireless infrastructure, making it a promising enabler of reliable Vehicle-to-Everything (V2X) communication in complex urban environments.
Abdul Rehman, Husnain Shahid, Barbara M. Masini, Piergiuseppe Di Marco, Fakiha Munawar   +4 more
doaj   +1 more source