Results 61 to 70 of about 426,649 (304)

Dual-Antigen Subunit Vaccine Nanoparticles for Scrub Typhus

Pathogens, 2023
Orientia tsutsugamushi is the causative pathogen of scrub typhus, an acute febrile disease prevalent in the Asia–Pacific region that is spread to people through chigger bites. Despite the emerging threat, there is no currently available vaccine against O.
Jaeyoung Park, Zhiwen Zhang, Tatyana Belinskaya, Alexandra N. Tsoras, Chien-Chung Chao, Le Jiang, Julie A. Champion   +6 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Induction of humoral immune response to multiple recombinant Rhipicephalus appendiculatus antigens and their effect on tick feeding success and pathogen transmission [PDF]

, 2016
BACKGROUND: Rhipicephalus appendiculatus is the primary vector of Theileria parva, the etiological agent of East Coast fever (ECF), a devastating disease of cattle in sub-Saharan Africa.
A Musoke, A Musoke, AR Trimnell, AR Trimnell, AR Walker, AS Bowman, AS Young, AS Young, B Minjauw, C Almazán, C Almazán, C Almazán, C Almazán, CA Ferreira, Cassandra L. Olds, CL Schwartzkoff, Claudia Daubenberger, David O. Odongo, DO Odongo, DO Odongo, G Büscher, GC Paesen, GJ Rowlands, Glen A. Scoles, H Ochanda, I Couillin, J Fuente de la, J Fuente de la, J Fuente de la, J Fuente de la, J Fuente de la, J Katende, JD Hunt, JD Hunt, JG Valenzuela, JH Pruett, JM Ribeiro, JO Adejinmi, K Bailey, KM Kocan, M Labuda, M Saimo, M Shakya, MP Szabó, NA Steen, NH Ogden, O Merino, O Merino, P Willadsen, P Willadsen, P Willadsen, PG Toye, R Bishop, R Bishop, RA Skilton, RAI Norval, RC Galindo, Richard Bishop, S Havlíková, SK Wikel, Stephen Mwaura, T Bazarusanga, T Schetters, TT Dolan, V Nene, Z Zivkovic   +65 more
core   +3 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Function-guided selection of salivary antigens from Ornithodoros erraticus argasid ticks and assessment of their protective efficacy in rabbits

Ticks and Tick-Borne Diseases, 2023
The identification of new protective antigens for the development of tick vaccines may be approached by selecting antigen candidates that have key biological functions.
Ángel Carnero-Morán, Ana Oleaga, Ana Laura Cano-Argüelles, Ricardo Pérez-Sánchez   +3 more
doaj   +1 more source

Radioimmunoassay for Gram-negative bacterial lipopolysaccharide O antigens: influence of antigen solubility [PDF]

Infection and Immunity, 1979
We have developed a solid-phase radioimmunoassay technique for specific gram-negative bacterial lipopolysaccharide (LPS) O antigens. The method exploits the high-titer, specific immunoglobulin M response of the rabbit to LPS immunization to measure as little as 5 ng of homologous LPS per ml with less than 0.5% cross-reactivity toward heterologous LPS ...
R S, Munford, C L, Hall
openaire   +2 more sources

Recognition of viral glycoproteins by influenza A-specific cross- reactive cytolytic T lymphocytes [PDF]

, 1980
Two populations of cytolytic T lymphocytes (CTL) generated after influenza A virus infection can be distinguished into one with specificity for the sensitizing hemagglutinin type and a second with cross-reactivity for antigens induced by other type-A ...
Allen, H., Gething, M. J., Klenk, H. D., Koszinowski, Ulrich H., Waterfield, M. D.   +4 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

O-Antigen Modulates Infection-Induced Pain States

PLoS ONE, 2012
The molecular initiators of infection-associated pain are not understood. We recently found that uropathogenic E. coli (UPEC) elicited acute pelvic pain in murine urinary tract infection (UTI). UTI pain was due to E. coli lipopolysaccharide (LPS) and its receptor, TLR4, but pain was not correlated with inflammation.
Charles N Rudick, Mingchen Jiang, Ryan E Yaggie, Vladimir I Pavlov, Joseph Done, Charles J Heckman, Christopher Whitfield, Anthony J Schaeffer, David J Klumpp   +8 more
openaire   +4 more sources

Induction of specific tolerance by intrathymic injection of recipient muscle cells transfected with donor class I major histocompatibility complex. [PDF]

, 1994
Induction of tolerance to allogeneic MHC antigens has been a goal in the field of transplantation because it would reduce or eliminate the need for generalized immunosuppression.
Geissler, Edward K., Jiao, Shoushu, Knechtle, Stuart J., Sumimoto, Ryo, Wang, Jue, Wolff, Jon   +5 more
core   +1 more source