Results 111 to 120 of about 2,519,772 (150)

Structure-Based Discovery of Obeticholic Acid Derivatives as Novel Farnesoid X Receptor Partial Agonists with Improved Selectivity and Reduced Off-Target Effects. [PDF]

ChemMedChem
Passeri D, Cerra B, Carotti A, Greco F, Piermarini S, Colliva C, Liscio P, De Franco F, Adorini L, Erickson MR, Pellicciari R, Gioiello A.   +11 more
europepmc   +1 more source

Unveiling a novel macrophage-driven mechanism for obeticholic acid-induced liver injury in cholestatic: targeting NLRP12^Arg185 fuels Relb-TNFSF14-mediated ductular reaction. [PDF]

Cell Biol Toxicol
Wang J, Yuan Z, Zhang H, Tang Q, Miao Y, Li A, Chen Q, Zhou X, Yu Q, Zhang L, Jiang Z.   +10 more
europepmc   +1 more source

Second-Line Therapies in Primary Biliary Cholangitis: A Comparative Review of Obeticholic Acid, Fibrates, Seladelpar, and Elafibranor. [PDF]

Biomedicines
Jamal F, Elshaer A, Alatout MH, Odeh NB, Youssef A, Abo Abdullah H, Elmasry S, Shahin T, Abdul Nabi H, Worden AR, Malik TA, Lizaola-Mayo BC.   +11 more
europepmc   +1 more source

Hepatic angiosarcoma in a patient treated with obeticholic acid for primary biliary cholangitis. [PDF]

Hepatol Forum
Arif AA, Punnen S, Bleszynski M, Daniel R O, Yoshida EM.   +4 more
europepmc   +1 more source

Long-term effectiveness, safety, and liver stiffness dynamics of PBC treatment with obeticholic acid in real-world. [PDF]

JHEP Rep
Terracciani F, De Vincentis A, D'Amato D, Cristoferi L, Gerussi A, Invernizzi P, Scaravaglio M, Vanni E, Campion D, Morgando A, Valiani V, Boccaccio V, Morisco F, Surace L, Cavalli I, Delle Monache G, Salomone F, Ieluzzi D, Angrisani D, Tortora R, Cuffari B, Moretti A, Nardone G, Fagiuoli S, Viganò M, Vettori G, Cerini F, Gimignani G, Mattalia A, Pizzolante F, De Matthaeis N, Rigamonti C, Manfredi GF, Boano V, Begini P, Lleo A, Colapietro F, Plebani R, Alvaro D, Venere R, Degasperi E, Borghi M, Lampertico P, Giannini EG, Labanca S, Viganò R, D'Amico F, Castellaneta A, Squeo F, Cadamuro L, Capodicasa L, Marzioni M, Buzzanca V, Poggi G, Mussetto A, Cozzolongo R, Losito F, Bertino G, Russello M, Cannavò M, Scivetti P, Pompili M, Tortora A, Niro AG, Cotugno R, Pozzoni P, Riva A, Chessa L, Miglianti M, Cuccorese G, Pace Palitti V, Abenavoli L, Terreni N, Zolfino T, Morelli O, Saitta C, Casella S, Pellicelli A, Brunetto M, Coco B, Galli A, Marra F, Curto A, Floreani A, Cazzagon N, Rollo P, Bonaiuto E, Simone L, Muratori L, Rosina F, Distefano M, Capello E, Bellia V, Sacco R, Alagna G, Baiocchi L, Crocé LS, Ricci C, Poisa P, Izzi A, Boninsegna S, Calvaruso V, Carbone M, Vespasiani-Gentilucci U, “Italian PBC registry” and the “Club Epatologi Ospedalieri” PBC working group.   +104 more
europepmc   +1 more source

Tailoring obeticholic acid activity by iridium(III) complex conjugation to develop a farnesoid X receptor probe. [PDF]

J Adv Res
Niu D, Wu X, Zhang Y, Wang X, Shiu-Hin Chan D, Jing S, Wong CY, Wang W, Leung CH.   +8 more
europepmc   +1 more source

Tenascin C-Guided Nanosystem for Precision Delivery of Obeticholic Acid in Liver Fibrosis Therapy. [PDF]

Pharmaceutics
Wang Y, Yang L, Xu Q, Liu T, He H, Liu L, Yin L.   +6 more
europepmc   +1 more source

Hepatic real-world outcomes with obeticholic acid in primary biliary cholangitis (HEROES): A trial emulation study design. [PDF]

Hepatology
Brookhart MA, Mayne TJ, Coombs C, Breskin A, Ness E, Bessonova L, Chu YJ, Li J, Fried MW, Hansen BE, Kowdley KV, Jones D, Mells G, Trivedi PJ, Hiu S, Kareithi DN, Wason J, Smith R, Seeger JD, Hirschfield GM.   +19 more
europepmc   +1 more source

Obeticholic Acid Improves Cholestasis, Liver Fibrosis, and Liver Function in Patients with Primary Biliary Cholangitis with Inadequate Response to Ursodeoxycholic Acid. [PDF]

J Pers Med
Buechter M, Manka P, Bulut K, Gerken G, Kahraman A.   +4 more
europepmc   +1 more source

COBALT: A Confirmatory Trial of Obeticholic Acid in Primary Biliary Cholangitis With Placebo and External Controls. [PDF]

Am J Gastroenterol
Kowdley KV, Hirschfield GM, Coombs C, Malecha ES, Bessonova L, Li J, Rathnayaka N, Mells G, Jones DE, Trivedi PJ, Hansen BE, Smith R, Wason J, Wason J, Hiu S, Kareithi DN, Mason AL, Bowlus CL, Muller K, Carbone M, Berenguer M, Milkiewicz P, Adekunle F, Villamil A.   +23 more
europepmc   +1 more source