Results 91 to 100 of about 6,340 (200)

Obeticholic Acid and Insulin Sensitivity in Overweight Patients with Prediabetes

Ожирение и метаболизм
BACKGROUND. Due to its role as a risk factor for the emergence of metabolic illnesses including type 2 diabetes, cardiovascular disease, and certain cancers with pandemic evolution, obesity is a serious public health concern.
H. Amer, M. Nesim, H. Mansour, E. Nasr, N. Ahmed   +4 more
doaj   +1 more source

Bioequivalence and Pharmacokinetic Profiles of Generic and Branded Obeticholic Acid in Healthy Chinese Subjects Under Fasting and Fed Conditions

Drug Design, Development and Therapy, 2021
Meng-Na Wang,1,* Hai-Tao Yu,2,* Ya-Qian Li,1 Yun Zeng,1 Shuang Yang,3 Guo-Ping Yang,1,3– 6 Qi Pei,6 Jie Huang1,3 1Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, People’s ...
Wang MN, Yu HT, Li YQ, Zeng Y, Yang S, Yang GP, Pei Q, Huang J   +7 more
doaj  

Multimodal Cross‐Attentive Graph‐Based Framework for Predicting In Vivo Endocrine Disruptors

Advanced Science, Volume 13, Issue 21, 13 April 2026.
A multimodal cross‐attentive graph neural network integrates molecular graphs with androgen and estrogen adverse outcome pathway (AOP)–anchored in vitro assay signals to predict in vivo endocrine disruption. By fusing information on Tier‐1 AOP logits with chemical structures, the framework achieves high accuracy and provides assay‐traceable ...
Eder Soares de Almeida Santos, Gustavo Felizardo Santos Sandes, Artur Christian Garcia da Silva, Holli‐Joi Martin, Eugene N. Muratov, Rodolpho de Campos Braga, Bruno Junior Neves   +6 more
wiley   +1 more source

Revisiting Parenteral Nutrition-Associated Liver Disease (PNALD) [PDF]

, 2017
Parenteral Nutrition-Associated Liver Disease (PNALD) causes progressive cholangitis which can lead to liver failure and cirrhosis especially in infants.
Pullicino, Edgar
core  

Role of aetiology in the progression, regression, and parenchymal remodelling of liver disease: implications for liver biopsy interpretation [PDF]

, 2016
Clinicopathological concepts on acute and chronic liver disease have evolved rapidly during the last few years, with advances in general and specific treatment options and improved patient outcomes.
Alberto Quaglia, Amar P Dhillon, Charles Balabaud, Dale C Snover, Dirk J van Leeuwen, James M Crawford, Linda Ferrell, Maria Guido, Neil D Theise, null null, Paulette Bioulac-Sage, Prithi S Bhathal, Prodromos Hytiroglou, Swan N Thung, Valerie Paradis, Venancio A Alves, Wilson M S Tsui, Yasuni Nakanuma   +17 more
core   +2 more sources

Microengineering the Liver: Strategies for Constructing Functional Liver‐on‐a‐Chip Devices

Exploration, Volume 6, Issue 2, April 2026.
This review summarizes recent advances in liver‐on‐a‐chip (LOC) technologies, including fabrication strategies and functional integration approaches, and discusses their promising applications in drug screening and related biomedical fields. ABSTRACT Reliable in vitro liver models are indispensable for researching liver diseases and developing ...
Jie Wang, Ziwei Liang, Jiapu Wang, Zongyi Li, Shaojie Wang, Yan Wei, Xin Xie, Di Huang   +7 more
wiley   +1 more source

A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis [PDF]

, 2017
The aim of this study was to evaluate cenicriviroc (CVC), a dual antagonist of C-C chemokine receptor types 2 and 5, for treatment of nonalcoholic steatohepatitis (NASH) with liver fibrosis.
Abdelmalek, Manal F., Aithal, Guruprasad P., Caballeria, Juan, Craxi, Antonio, Farrell, Geoffrey, Fischer, Laurent, Francque, Sven, Friedman, Scott L., Goodman, Zachary, Harrison, Stephen A., Kowdley, Kris V., Lefebvre, Eric, Loomba, Rohit, Melchor-Khan, Liza, Ratziu, Vlad, Sanyal, Arun, Seyedkazemi, Star, Simon, Krzysztof, Tacke, Frank, Vest, Jeffrey, Vig, Pamela, Wiens, Brian L., Wong, Vincent Wai-Sun   +22 more
core   +5 more sources

Development of NAFLD‐Specific Human Liver Organoid Models on a Microengineered Array Chip for Semaglutide Efficacy Evaluation

Cell Proliferation, Volume 59, Issue 4, April 2026.
Microporous array organ chips were integrated with commercially available well plates to develop organoid chip platforms, which enable modelling of hepatic physiology and non‐alcoholic fatty liver disease (NAFLD) pathogenesis, as well as evaluation of semaglutide therapeutics. ABSTRACT Progressive non‐alcoholic fatty liver disease (NAFLD) may culminate
Xiao‐yan You, Xiang‐yang Li, Hui Wang, Guo‐ping Zhao   +3 more
wiley   +1 more source

Salvianolic Acid B Alleviates MAFLD by Targeting PPAR‐α: Mechanistic Insights From Network Pharmacology and Lipidomics

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Salvianolic acid B (SALB) is the major water‐soluble bioactive constituent of Salvia miltiorrhiza Bunge, a traditional Asian health‐promoting food, while its therapeutic potential and molecular mechanisms in the pathogenesis of MAFLD remain largely unclear.
Fengyan Huang, Chen Qiu, Danna Wang, Yuanying Ni, Zhuotao Fu, Linchun Fu, Chao Liang, Shangyi Huang, Zhitong Deng   +8 more
wiley   +1 more source

Therapeutic Potential of Saikosaponins in MASLD and Cross‐Organ Protection: A Research Update

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
This review systematically outlines the multi‐target mechanisms of Saikosaponins (SSs) against MASLD, encompassing the regulation of lipid metabolism, insulin resistance, and inflammatory response. Furthermore, it highlights their novel cross‐organ protective effects on the cardiovascular, renal, and central nervous systems, providing therapeutic ...
Jiayao Xiong, Wanyan Tan, Ze Jin, Xiangyu Li, Yuting Chen, Wanting Xie   +5 more
wiley   +1 more source