Results 71 to 80 of about 2,519,772 (150)

Beyond Weight Loss: Tirzepatide as a Metabolic Disease‐Modifying Strategy for Metabolic Dysfunction‐Associated Steatohepatitis: A Narrative Review

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide and a major contributor to liver‐related morbidity and mortality. Its progressive subtype, metabolic dysfunction–associated steatohepatitis (MASH), is characterized by hepatocellular injury, inflammation,
Zubaier Ahmed, Nashrah Mustafa, Tamanna Sarkar, Hasina Yasmin   +3 more
wiley   +1 more source

Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases

Frontiers in Medicine, 2020
In the past ten years, our understanding of the importance of bile acids has expanded from fat absorption and glucose/lipid/energy homeostasis into potential therapeutic targets for amelioration of chronic cholestatic liver diseases.
Vik Meadows, Vik Meadows, Lindsey Kennedy, Debjyoti Kundu, Gianfranco Alpini, Gianfranco Alpini, Heather Francis, Heather Francis   +7 more
doaj   +1 more source

Obeticholic acid for the treatment of primary biliary cirrhosis

Introduction: There is significant unmet need in Primary Biliary Cholangitis (PBC) in patients under-responsive to the only approved therapy Ursodeoxycholic Acid (UDCA) who are at increased risk of progressing to end-stage liver disease. Obeticholic Acid
Jones DEJ
core   +4 more sources

Primary Biliary Cholangitis With Incomplete Response to Conventional Therapies But Had Complete Response to Baricitinib: A Case Report

Case Reports in Hepatology
Primary biliary cholangitis is a progressive disease with complications such as liver cirrhosis and hepatocellular carcinoma, and the treatment goal is to delay its progression.
Gi Eun Kim, Mariam Imran, Sherif Mostafa, Yasser Kamel   +3 more
doaj   +1 more source

Multiple roles of bile acids in ferroptosis regulation: Opportunities for disease therapy

Pharmacological Research
Bile acids (BAs), the main component of bile, play a key role in the digestion of lipids. However, recent studies have demonstrated that BAs can also act as signaling molecules, regulating metabolism by binding to BA receptors.
Nan Wu, Shuang Yu, Xiaoqi Wei, Lina Yang, Xiaowen Zhang   +4 more
doaj   +1 more source

The use of obeticholic acid for the management of non-viral liver disease: current clinical practice and future perspectives

, 2017
Introduction: Farnesoid X nuclear receptor is involved in the regulation of lipid and glucose metabolism, though mainly in the homeostasis of bile acids. Indeed, the agonists of farnesoid X nuclear receptor represent promising drugs.
Stefano Gitto, Guarneri, Valeria, Andreone, Pietro, Gitto, Stefano, Valeria Guarneri, Sartini, Alessandro, Pietro Andreone, Alessandro Sartini   +7 more
core   +1 more source

Obeticholic acid for the treatment of primary biliary cirrhosis [PDF]

, 2016
Primary biliary cirrhosis (PBC) is characterized by progressive nonsuppurative destruction of small bile ducts, resulting in intrahepatic cholestasis, fibrosis and ultimately end-stage liver disease.
Hirschfield, Gideon M, Trivedi, Palak J, Gershwin, M Eric   +2 more
core   +1 more source

Role of Farnesoid X Receptor Ligand Obeticholic Acid Versus Vitamin E for Patients with Nonalcoholic Steatohepatitis [PDF]

Al-Azhar International Medical Journal
Background: Non-alcoholic fatty liver disease (NAFLD) is a leading metabolic disorder that commonly progresses to non-alcoholic steatohepatitis (NASH), potentially complicated with cirrhosis, liver failure, and hepatocellular carcinoma.Aim: To compare ...
doaj   +1 more source

Obeticholic acid reduces bacterial traslocation, restores intestinal barrier and inhibits inflammation in cirrhotic rats

, 2016
9 p.Background & aims: In advanced cirrhosis, gut bacterial translocation is the consequence of intestinal barrier disruption and leads to bacterial infection.
Pastor Rojo, Óscar, Lledó García, María Lourdes, Sánchez Díaz, Ana María, Borrero Corte, María José, Rodríguez Serrano, Macarena, Álvarez De Mon Soto, Melchor, García Bermejo, María Laura, Muñoz Zamarrón, María Leticia, Campo Moreno, Rosa del, Díaz Martín, David, Lario Martínez, Margaret, Úbeda Cantera, María del Pilar, Albillos Martínez, Agustín   +12 more
core   +1 more source

Supplementary_Material – Supplemental material for Synthesis and characterization of new impurities in obeticholic acid

, 2019
Supplemental material, Supplementary_Material for Synthesis and characterization of new impurities in obeticholic acid by Wei-Dong Feng, Song-Ming Zhuo and Fu-Li Zhang in Journal of Chemical ...
Wei-Dong Feng (5635334), Song-Ming Zhuo (5635337), Fu-Li Zhang (2855801)   +2 more
core   +1 more source