Results 51 to 60 of about 6,340 (200)

The relationship between gut microbiota and spontaneous bacterial peritonitis in patients with liver cirrhosis - a literature review [PDF]

, 2019
Gut microbiota is an essential component in the pathogenesis of liver cirrhosis and its complications. There is a direct relationship between the gut and the liver called the gutliver axis through which bacteria can reach the liver through the portal ...
Fierbinteanu Braticevici, Carmen, Mazilu, Laura, Motofei, Catalina, Pantea Stoian, Anca Mihaela, Parepa, Irinel R., Paunica, Mihai, Popoiag, Roxana-Emanuela, Serban, Laura M., Suceveanu, Adrian P., Suceveanu, Andra I.   +9 more
core   +3 more sources

In Silico Analysis Identifies Intestinal Transit as a Key Determinant of Systemic Bile Acid Metabolism [PDF]

, 2018
Bile acids fulfill a variety of metabolic functions including regulation of glucose and lipid metabolism. Since changes of bile acid metabolism accompany obesity, Type 2 Diabetes Mellitus and bariatric surgery, there is great interest in their role in ...
Eggink, Hannah M, Groen, Albert K, Hilbers, Peter A J, Sips, Fianne L P, Soeters, Maarten R, van Riel, Natal A W   +5 more
core   +3 more sources

Enzyme‐Activated MRI for In Vivo Glucose Imaging via a Biodegradable Chromium Nanoprobe

Advanced Science, EarlyView.
Enzyme‐activated MRI (eaMRI) using a biodegradable CrGOx@Lip nanoprobe enables glucose‐specific imaging in vivo. GOx catalyzes glucose oxidation, triggering in situ formation of paramagnetic chromium gluconate and amplifying T1. This radiation‐free strategy maps tumor glucose uptake via the Warburg‐effect, quantifies hepatic glucose accumulation in ...
Yan Xu, Weitao Yang, Yanjing Yun, Hui Wang, Zhuoyao Wu, Youyi Yu, Bingbo Zhang   +6 more
wiley   +1 more source

New treatments/targets for primary biliary cholangitis

JHEP Reports, 2019
Summary: Primary biliary cholangitis (PBC) is an autoimmune, cholestatic, chronic liver disease that ultimately progresses towards cirrhosis and liver failure if untreated.
Christophe Corpechot, Raoul Poupon, Olivier Chazouillères   +2 more
doaj   +1 more source

Effects of Intestinal FXR-Related Molecules on Intestinal Mucosal Barriers in Biliary Tract Obstruction

Frontiers in Pharmacology, 2022
Background: The farnesoid X receptor (FXR) is a key factor regulating hepatic bile acid synthesis and enterohepatic circulation. Repression of bile acid synthesis by the FXR is a potential strategy for treating cholestatic liver disease.
Meng Yan, Meng Yan, Li Hou, Yaoyao Cai, Hanfei Wang, Yujun Ma, Qiming Geng, Weiwei Jiang, Weibing Tang   +8 more
doaj   +1 more source

Non-Alcoholic Steatohepatitis: Limited Available Treatment Options but Promising Drugs in Development and Recent Progress Towards a Regulatory Approval Pathway [PDF]

, 2015
The prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) is increasing world-wide in parallel to the increase of the obesity epidemic.
Filozof, Claudia, Goldstein, Barry J., Sanyal, Arun, Williams, Richard N.   +3 more
core   +2 more sources

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, EarlyView.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source

Biliary Bicarbonate Secretion Constitutes a Protective Mechanism against Bile Acid-Induced Injury in Man [PDF]

, 2011
Background: Cholangiocytes expose a striking resistance against bile acids: while other cell types, such as hepatocytes, are susceptible to bile acid-induced toxicity and apoptosis already at micromolar concentrations, cholangiocytes are continuously ...
Amelsberg A, Batzri S, Beuers U, Beuers U, Douglas M. Jefferson, Duane WC, Eastwood GL, Hofmann AF, Hohenester S, Hov JR, Lucas Maillette de Buy Wenniger, Medina JF, Melero S, Minagawa N, Poupon R, Prieto J, Prieto J, Ronald P. Oude Elferink, Rust C, Simon Hohenester, Spivey JR, Ulrich Beuers   +21 more
core   +1 more source

Farnesoid X receptor prevents hyperuricemia via activating ATP‐binding cassette subfamily G member 2

Rheumatology &Autoimmunity, EarlyView.
Farnesoid X receptor (FXR) activation reduces serum uric acid levels by upregulating the intestinal urate transporter ATP‐binding cassette subfamily G member 2 (ABCG2). These findings uncover a novel metabolic pathway for urate excretion and suggest that FXR agonists (e.g., obeticholic acid), represent a promising therapeutic strategy for the treatment
Rui Li, Guo Tang, Ye Yu, Guang‐Liang Chen, Liangjing Lu, Juan Wang   +5 more
wiley   +1 more source

Experimental Pharmacological Agents for the Treatment of Primary Biliary Cholangitis

Journal of Experimental Pharmacology, 2020
Annarosa Floreani1,2 1University of Padova, Padova, Italy; 2Scientific Institute for Research, Hospitalization and Healthcare, Negrar, Verona, ItalyCorrespondence: Annarosa FloreaniUniversity of Padova, Padova, ItalyTel +10393899418841Email annarosa ...
Floreani A
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