Results 81 to 90 of about 2,519,772 (150)

Long-term efficacy and safety of obeticholic acid for patients with primary biliary cholangitis: 3-year results of an international open-label extension study

, 2019
BACKGROUND: The aim of this study was to evaluate the long-term efficacy and safety of obeticholic acid for patients with primary biliary cholangitis using 3-year interim data from the 5-year open-label extension of the pivotal phase 3 POISE trial ...
Andreone, P., Pencek, Richard, Drenth J. P. H., Trauner, M., Shapiro D., Drenth, J.P.H., Bowlus, C.L., Vargas, Victor, Nevens, Frederik, Shapiro, David, Hirschfield, Gideon M., Vargas, V., Pencek, R., Trauner, Michael, Malecha, E.S., Drenth, Joost P.H., Pencek R., Shiffman, M.L., Andreone P., Hirschfield G. M., Hirschfield, G.M., Vargas V., MacConell L., Andreone, Pietro, MacConell, Leigh, Malecha, Elizabeth Smoot, Trauner M., Shiffman, Mitchell L., Nevens F., Shapiro, D., Bowlus, Christopher L., Shiffman M. L., Bowlus C. L., Nevens, F., Malecha E. S., MacConell, L.   +35 more
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In Silico Study of Obeticholic Acid Analogs as FXR Agonists

Chemistry Proceedings
Nuclear receptors are ligand-activated transcription factors that, in response to lipophilic hormones, vitamins, and dietary lipids, regulate numerous aspects of mammalian physiology. Bile acid receptors represent well-defined targets for the development
Julio A. Seijas, Silvia Vázquez-Gómez, Francisco Meijide, M. Pilar Vázquez-Tato   +3 more
doaj   +1 more source

The synthesis of fluorinated obeticholic acid derivatives

, 2021
Bile acids are steroids found naturally within the bile of humans and other vertebrates. Their physiological roles involve the solubilisation of dietary lipids, lipophilic vitamins and drugs and also the regulation of hepatic cholesterol levels ...
Holland, Simon
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The cancerogenic potential of primary human Cholangioracinoma cells is inhibited by Obeticholic Acid, a Farnesoid X Receptor (FXR) agonist

, 2018
The cancerogenic potential of primary human Cholangioracinoma cells is inhibited by Obeticholic Acid, a Farnesoid X Receptor (FXR ...
Colantonio M., Costantini D., Napoletano C., Grazi G., Giuliante F., Safarikia S., Giulitti F., Alvaro D., Carpino G., De Rose A. M., Berloco P. B., Manzi E., Nevi L., Cardinale V., Melandro F., Di Matteo S., Bragazzi M. C., Gaudio E.   +17 more
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A physico-chemical explanation for the litho-protective effects of obeticholic acid in low phospholipid-associated cholelithiasis

Patients with low phospholipid-associated cholelithiasis may suffer from recurrent biliary symptoms and complications despite cholecystectomy and ursodeoxycholic acid therapy. Recently, beneficial clinical effects of treatment with the potent Farnesoid X
Portincasa, Piero, Moschetta, Antonio, van Erpecum, Karel J., van Berge Henegouwen, Gerard P., MS MDL 1, Infection & Immunity, Cancer   +6 more
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Effect of obeticholic acid on liver regeneration following portal vein embolization in an experimental model

, 2017
The bile salt-activated transcription factor farnesoid X receptor (FXR) is a key mediator of proliferative bile salt signalling, which is assumed to play a role in the early phase of compensatory liver growth.
Heger, M., Damink, S. W. Olde, M Heger, van Lienden, K. P., F Huisman, F G Schaap, Schaap, F. G., T M van Gulik, R J Bennink, R F van Golen, Huisman, F., Verheij, J., van Gulik, T. M., Bennink, R. J., van Golen, R. F., Jansen, P. L., S W Olde Damink, Olthof, P. B., Damink, S. W. Olde; id_orcid, Olde Damink, S. W., K P van Lienden, P L Jansen, P B Olthof, J Verheij   +23 more
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Unravelling the therapeutic landscape of bile acid-based therapies in gastrointestinal disorders

The Saudi Journal of Gastroenterology
Bile acids serve as endogenous ligands for nuclear and cell membrane receptors and play a crucial role in bile acid and lipid metabolism. These detergent-like compounds promote bile flow and aid in the absorption of dietary fats and fat-soluble vitamins ...
Bandar D. Alrehaili
doaj   +1 more source

Obeticholic acid: expanding the therapeutic landscape of NASH

Annals of Hepatology, 2015
Marco Arrese, Daniel Cabrera, Francisco Barrera   +2 more
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Real-world treatment patterns and clinical outcomes of patients with primary biliary cholangitis in the United States

Journal of Comparative Effectiveness Research
Background & aim: Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease that can lead to increased morbidity and mortality. This study described real-world treatment patterns and clinical outcomes by line of treatment among patients ...
Nisreen Shamseddine, Hongbo Yang, Su Zhang, Dongni Ye, Shravanthi Seshasayee, Jingyi Chen, Sonal Kumar, Kris V Kowdley   +7 more
doaj   +1 more source

DataSheet1_Inhibition of ACOX1 enhances the therapeutic efficacy of obeticholic acid in treating non-alcoholic fatty liver disease and mitigates its lipotoxicity.docx

Background and aims:High-dose Obeticholic acid exhibits promise for non-alcoholic fatty liver disease (NAFLD) treatment but can induce lipotoxicity.
Biao Nie (1818937), Chuangzhen Lin (12516919), Kun He (178646), Yuping Yang (3874810), Shenshen Du (17546746), Weinan Yuan (6532982), Yanqi Kou (18257407)   +6 more
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