Results 11 to 20 of about 2,519,772 (150)

Content determination of obeticholic acid tablets by HPLC

Journal of Hebei University of Science and Technology, 2017
In order to establish a method for the content determination of obeticholic acid tablets, HPLC-UV method is adopted. The determination is performed on Agilent HC-C18 column（250 mm×4.6 mm,5 μm） with mobile phase acetonitrile (002% formic acid)-water (0 ...
Yunxia LU, Xingyan PAN, Jun YAO
doaj   +2 more sources

Obeticholic Acid—A Pharmacological and Clinical Review

Future Pharmacology, 2023
Obeticholic acid (OCA) or 6-alpha-ethyl-chenodeoxycholic acid is a semisynthetic modified bile acid derivative that acts on the farnesoid X receptor (FXR) as an agonist with a higher potency than bile acid.
Caezaan Keshvani, Jonathan Kopel, Hemant Goyal   +2 more
doaj   +2 more sources

Obeticholic acid for the treatment of primary biliary cholangitis in adult patients: clinical utility and patient selection [PDF]

Hepatic Medicine: Evidence and Research, 2016
Christopher L Bowlus Division of Gastroenterology and Hepatology, University of California Davis, Davis, CA, USA Abstract: Primary biliary cholangitis (PBC), previously known as primary biliary “cirrhosis”, is a rare autoimmune liver disease ...
Bowlus CL
doaj   +2 more sources

Effects of apical sodium-bile acid transporter inhibitor and obeticholic acid co-treatment in experimental non-alcoholic steatohepatitis [PDF]

Liver Research, 2022
Background and aims: Several bile acids-based monotherapies have been developed for non-alcoholic steatohepatitis (NASH) treatment but clinical trial findings suggest that they do not satisfactorily improve NASH and liver fibrosis in many patients ...
David J. Matye, Xuan Qin, Mohammad Nazmul Hasan, Lijie Gu, Yung Dai Clayton, Feng Li, Tiangang Li   +6 more
doaj   +2 more sources

Obeticholic Acid and Insulin Sensitivity in Overweight Patients with Prediabetes

Ожирение и метаболизм
BACKGROUND. Due to its role as a risk factor for the emergence of metabolic illnesses including type 2 diabetes, cardiovascular disease, and certain cancers with pandemic evolution, obesity is a serious public health concern.
H. Amer, M. Nesim, H. Mansour, E. Nasr, N. Ahmed   +4 more
doaj   +2 more sources

New developments in the treatment of primary biliary cholangitis – role of obeticholic acid

Therapeutics and Clinical Risk Management, 2017
Manan A Jhaveri, Kris V Kowdley Liver Care Network, Swedish Medical Center, Seattle, WA, USA Abstract: Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease that predominantly affects women in early to middle age.
Jhaveri MA, Kowdley KV
doaj   +1 more source

Hepatic‐Accumulated Obeticholic Acid and Atorvastatin Self‐Assembled Nanocrystals Potentiate Ameliorative Effects in Treatment of Metabolic‐Associated Fatty Liver Disease [PDF]

Advanced Science
Exploration of medicines for efficient and safe management of metabolic‐associated fatty liver disease (MAFLD) remains a challenge. Obeticholic acid (OCA), a selective farnesoid X receptor agonist, has been reported to ameliorate injury and inflammation ...
Huanfen Lu, Zhenglan Ban, Kai Xiao, Madi Sun, Yongbo Liu, Fangman Chen, Tongfei Shi, Li Chen, Dan Shao, Ming Zhang, Wei Li   +10 more
doaj   +2 more sources

INSIGHTS INTO THE IMPACT OF FXR ACTIVATION ON HEPATIC AUTOPHAGY IN A NON-ALCOHOLIC STEATOHEPATITIS MODEL [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2021
Background: Multiple lines of evidence pointed to the role of dysbiosis, small intestinal bacterial overgrowth and altered intestinal permeability in promoting pro-inflammatory events in the liver leading to the progression of steatosis to non-alcoholic ...
Dalaal Abdallah, Mohamed Elmazar, Olfat Hammam, Noha Nassar, Yasmeen Attia, Rasha Tawfiq   +5 more
doaj   +1 more source

27558 Obeticholic acid (OCALIVA ®) protects against 2,8-dihydroxyadenine nephropathy in mice

Journal of Clinical and Translational Science, 2021
IMPACT: This work may lead to new treatments for crystalline nephropathies. OBJECTIVES/GOALS: This study investigated obeticholic acid (OCALIVA ®) as a potential treatment for 2,8-dihydroxyadenine (2,8-DHA) nephropathy using a mouse model.
Bryce Jones, Carlos Benitez, Idalia Cruz, Komuraiah Myakala, Xiaoxin Wang, Andrew Libby, Emma Rowland, Ryan Kurtz, Avi Rosenberg, Moshe Levi   +9 more
doaj   +1 more source

Efficacy and Safety of Obeticholic Acid for Treating Hepatic Steatosis in Patients With Familial Partial Lipodystrophy.

J Clin Endocrinol Metab
The attached file includes supplementary tables. This submission meets the Extended Data Sets and Supplemental Materials requirements that are included in author guidelines for the Journal of Clinical Endocrinology & Metabolism (Print ISSN 0021-972X,
Garg A, Vasandani C, Li X, Quittner C, Yokoo T.   +4 more
europepmc   +3 more sources