Results 21 to 30 of about 6,340 (200)

Hepatic‐Accumulated Obeticholic Acid and Atorvastatin Self‐Assembled Nanocrystals Potentiate Ameliorative Effects in Treatment of Metabolic‐Associated Fatty Liver Disease [PDF]

Advanced Science
Exploration of medicines for efficient and safe management of metabolic‐associated fatty liver disease (MAFLD) remains a challenge. Obeticholic acid (OCA), a selective farnesoid X receptor agonist, has been reported to ameliorate injury and inflammation ...
Huanfen Lu, Zhenglan Ban, Kai Xiao, Madi Sun, Yongbo Liu, Fangman Chen, Tongfei Shi, Li Chen, Dan Shao, Ming Zhang, Wei Li   +10 more
doaj   +2 more sources

Trials of obeticholic acid for non-alcoholic steatohepatitis [PDF]

Lancet, The, 2015
Giovanni Musso, Roberto Gambino
exaly   +6 more sources

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Impact of Obeticholic Acid and Moringaoleifera Leaf Extract on Arsenic induced Hepatotoxicity and Related Immunohistochemistry Changes in Adult Male Albino Rats [PDF]

International Journal of Medical Arts
Background:  A naturally occurring poison, arsenic can be found in food, soil, and water. Drinking water tainted with arsenic is the main way of exposure.
Fatma Noaman, Hamed Osman, Mohamed Abbas, Ashraf Emara   +3 more
doaj   +1 more source

Nonalcoholic steatohepatitis pharmacotherapy and predictors of response: dual role of aminotransferases as biosensors of metabolism and biomarkers of histological improvement [PDF]

, 2019
Nonalcoholic steatohepatitis (NASH)—the severe histological form of nonalcoholic fatty liver disease (NAFLD)—is regarded as a major health problem worldwide (1,2).
Pirola, Carlos José, Sookoian, Silvia Cristina   +1 more
core   +1 more source

The FXR agonist obeticholic acid inhibits the cancerogenic potential of human cholangiocarcinoma [PDF]

, 2019
Cholangiocarcinoma (CCA) is an aggressive cancer with high resistance to chemotherapeutics. CCA is enriched in cancer stem cells, which correlate with aggressiveness and prognosis.
Adorini, L., Alvaro, D., Berloco, P. B., Bragazzi, M., Cardinale, V., Carpino, G., Costantini, D., De Rose, A. M., Di Matteo, S., Gaudio, E., Giorgi, A., Giuliante, F., Giulitti, F., Grazi, G., Manzi, E., Melandro, F., Napoletano, C., Nevi, L., Overi, D., Safarikia, S.   +19 more
core   +3 more sources

Obeticholic acid—a new therapy in PBC and NASH [PDF]

British Medical Bulletin, 2020
Abstract Introduction Obeticholic acid (OCA) is a semi-synthetic hydrophobic bile acid (BA) analogue that is highly selective agonist of farnesoid X receptor (FXR), a key nuclear BA receptor, which induces expression of gut-derived hormones, in particular fibroblast growth factor 19.
Roger W Chapman, Kate D Lynch
openaire   +2 more sources

Content determination of obeticholic acid tablets by HPLC

Journal of Hebei University of Science and Technology, 2017
In order to establish a method for the content determination of obeticholic acid tablets, HPLC-UV method is adopted. The determination is performed on Agilent HC-C18 column（250 mm×4.6 mm,5 μm） with mobile phase acetonitrile (002% formic acid)-water (0 ...
Yunxia LU, Xingyan PAN, Jun YAO
doaj   +1 more source

Repurposing drugs to target nonalcoholic steatohepatitis [PDF]

, 2019
Nonalcoholic fatty liver disease (NAFLD) is a complex disorder that has evolved in recent years as the leading global cause of chronic liver damage.
Pirola, Carlos José, Sookoian, Silvia Cristina   +1 more
core   +1 more source

Primary Biliary Cholangitis and Bile Acid Farnesoid X Receptor Agonists

Diseases, 2020
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by the progressive destruction of the intrahepatic bile ducts. Currently, the first line drug for PBC is ursodeoxycholic acid (UDCA) characterized by anti-apoptotic ...
Ludovico Abenavoli, Anna Caterina Procopio, Sharmila Fagoonee, Rinaldo Pellicano, Marco Carbone, Francesco Luzza, Pietro Invernizzi   +6 more
doaj   +1 more source