Results 1 to 10 of about 196 (73)

Quantification of atropine sulphate monohydrate and obidoxime dichloride in two-chamber autoinjectors for accessing uniformity of dosage. [PDF]

Anal Sci Adv, 2022
Abstract In the treatment of organophosphate poisoning atropine sulphate monohydrate (AT) and obidoxime dichloride (OB) play a vital role. Currently, the Austrian Armed Forces use the DOUBLEPEN OA two‐chamber autoinjector (ChemProtect) to administer these two drugs.
Spreitzer I, Morawej P, Wosolsobe R, Stinzl R, Wackerlig J.   +4 more
europepmc   +2 more sources

Broad-Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve-Agent-Inhibited Acetylcholinesterase. [PDF]

Chemistry, 2022
Rational design of efficient antidotes to organophosphorus nerve agent (OPNA) intoxication needs to account for the complexity of the molecular system. A fragment with broad‐spectrum binding profile was transformed into a multi‐active reactivator of OPNAs‐inhibited acetylcholinesterases.
Lindgren C, Forsgren N, Hoster N, Akfur C, Artursson E, Edvinsson L, Svensson R, Worek F, Ekström F, Linusson A.   +9 more
europepmc   +2 more sources

Development of a combined solution formulation of atropine sulfate and obidoxime chloride for autoinjector and evaluation of its stability. [PDF]

Iran J Pharm Res, 2013
Atropine (AT) and oximes, alone or in combination, have been proven greatly valuable therapeutics in the treatment of organophosphates intoxications. An injectable mixture of AT and obidoxime (OB) was formulated for the administration by automatic self-injector.
Ettehadi HA, Ghalandari R, Shafaati A, Foroutan SM.   +3 more
europepmc   +3 more sources

Disentangling the formation, mechanism, and evolvement of the covalent methanesulfonyl fluoride acetylcholinesterase adduct: Insights into an aged-like inactive complex susceptible to reactivation by a combination of nucleophiles. [PDF]

Protein Sci
Abstract Chemical warfare nerve agents and pesticides, known as organophosphorus compounds inactivate cholinesterases (ChEs) by phosphorylating the serine hydroxyl group located at the active site of ChEs. Over the course of time, phosphorylation is followed by loss of an organophosphate‐leaving group and the bond with ChEs becomes irreversible, a ...
Stojan J, Pesaresi A, Meden A, Lamba D.
europepmc   +2 more sources

Pharmacokinetics and efficacy of atropine sulfate/obidoxime chloride co-formulation against VX in a guinea pig model [PDF]

Regulatory Toxicology and Pharmacology, 2021
Nerve agent exposure is generally treated by an antidote formulation composed of a muscarinic antagonist, atropine sulfate (ATR), and a reactivator of acetylcholinesterase (AChE) such as pralidoxime, obidoxime (OBI), methoxime, trimedoxime or HI-6 and an anticonvulsant.
Kentrop, J., Savransky, V., Klaassen, S.D., Groningen, T. van, Bohnert, S., Cornelissen, A.S., Cochrane, L., Barry, J., Joosen, M.J.A.   +8 more
openaire   +2 more sources

Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos [PDF]

Vojnosanitetski Pregled, 2011
Introduction/Aim. In acute organophosphate poisoning the issue of special concern is the appearance of muscle fasciculations and convulsions that cannot be adequately antagonised by the use of atropine and oxime therapy.
Antonijević Biljana, Stojiljković Miloš P., Bokonjić Dubravko, Vučinić Slavica   +3 more
doaj   +1 more source

Pro: Oximes should be used routinely in organophosphate poisoning

British Journal of Clinical Pharmacology, Volume 88, Issue 12, Page 5064-5069, December 2022., 2022
In poisoning with organophosphorus compounds (OP), patients can only profit from the regeneration of acetylcholinesterase, when the poison load has dropped below a toxic level. Every measure that allows an increase of synaptic acetylcholinesterase (AChE) activity at the earliest is essential for timely termination of the cholinergic crisis.
Horst Thiermann, Franz Worek
wiley   +1 more source

Transitioning from Oxime to the Next Potential Organophosphorus Poisoning Therapy Using Enzymes

Journal of Chemistry, Volume 2021, Issue 1, 2021., 2021
For years, organophosphorus poisoning has been a major concern of health problems throughout the world. An estimated 200,000 acute pesticide poisoning deaths occur each year, many in developing countries. Apart from the agricultural pesticide poisoning, terrorists have used these organophosphorus compounds to attack civilian populations in some ...
Rauda A. Mohamed, Keat K. Ong, Noor Azilah M. Kasim, Norhana A. Halim, Siti Aminah M. Noor, Victor F. Knight, Nurul Najwa Ab. Rahman, Wan Md Zin W. Yunus, Shafaqat Ali   +8 more
wiley   +1 more source

Optimal Choice of Acetylcholinesterase Reactivators for Antidoral Treatment of Nerve Agent Intoxication

Acta Medica, 2010
The studies dealing with mechanism of organophosphates (OP)/nerve agent action, prophylaxis and treatment of intoxications is a very hot topic at present.
Jiří Bajgar
doaj   +1 more source

A novel high‐performance liquid chromatography with diode array detector method for the simultaneous quantification of the enzyme‐reactivating oximes obidoxime, pralidoxime, and HI‐6 in human plasma

Drug Testing and Analysis, Volume 12, Issue 7, Page 938-947, July 2020., 2020
A HPLC‐DAD method was developed and validated for single and simultaneous quantification of obidoxime, pralidoxime, and HI‐6 for pharmacokinetic studies and clinical samples. Abstract Oximes such as pralidoxime (2‐PAM), obidoxime (Obi), and HI‐6 are the only currently available therapeutic agents to reactivate inhibited acetylcholinesterase (AChE) in ...
Tamara Kranawetvogl, Dirk Steinritz, Horst Thiermann, Harald John   +3 more
wiley   +1 more source