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1,1'-[Oxybis(methylene)]bis{4-[(hydroxyimino)methyl]pyridinium} dichloride (obidoxime chloride)
Acta Crystallographica Section B: Structural Crystallography and Crystal Chemistry, 1982A T H Lenstra, H J Geise
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Pharmacokinetics of obidoxime in patients poisoned with organophosphorus compounds
Toxicology Letters, 2010 Reactivation of inhibited acetylcholinesterase (AChE) with oximes is a causal therapy of intoxication with organophosphorus compounds (OPs). Maximal oxime effects are expected when effective doses are administered as soon as possible and as long as ...
Florian Eyer +2 more
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Obidoxime in acute organophosphate poisoning: 1 – clinical effectiveness
Clinical Toxicology, 2009 OBJECTIVE: The effects of obidoxime in the treatment of organophosphate poisoning were assessed by comparing the clinical course with its effects on laboratory parameters relevant to poisoning.
Florian Eyer +2 more
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Archives of Toxicology, 2007
The hydrolysis of acetylthiocholine iodide (ATCh) by pralidoxime chloride (2-PAM Cl), trimedoxime (TMB(4)) and obidoxime chlpride (LUH(6)) was studied at pH 5.8-8.0 and incubation temperature from 5 to 40 degrees C in vitro. Significant ATCh hydrolysis by 2-PAM Cl, TMB(4) and LUH(6) was found, with the exceptions of those at pH 7.0, 6.2 and 5.8 at 5 ...
Yi Hui, Zhang +4 more
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The hydrolysis of acetylthiocholine iodide (ATCh) by pralidoxime chloride (2-PAM Cl), trimedoxime (TMB(4)) and obidoxime chlpride (LUH(6)) was studied at pH 5.8-8.0 and incubation temperature from 5 to 40 degrees C in vitro. Significant ATCh hydrolysis by 2-PAM Cl, TMB(4) and LUH(6) was found, with the exceptions of those at pH 7.0, 6.2 and 5.8 at 5 ...
Yi Hui, Zhang +4 more
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Obidoxime in acute organophosphate poisoning: 2 – PK/PD relationships
Clinical Toxicology, 2009 OBJECTIVE: The effects of obidoxime in the treatment of organophosphate poisoning were assessed by biochemical and biological effect monitoring. In this article we report effects on neuromuscular function, oxime and atropine concentration, and relate ...
Florian Eyer +2 more
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PDA Journal of Pharmaceutical Science and Technology
Obidoxime chloride is an antidote for nerve gas intoxication. As an emergency medicine, it is being stored by the Israel Defense Forces (IDF) scattered throughout Israel in depots without a controlled environment (field conditions), thus being exposed to high and fluctuating temperatures. These conditions do not meet the manufacturer's requirements. In
Constantin, Itin +2 more
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Obidoxime chloride is an antidote for nerve gas intoxication. As an emergency medicine, it is being stored by the Israel Defense Forces (IDF) scattered throughout Israel in depots without a controlled environment (field conditions), thus being exposed to high and fluctuating temperatures. These conditions do not meet the manufacturer's requirements. In
Constantin, Itin +2 more
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[On the capacity of obidoxime chloride to reactivate phosphorylated blood cholinesterases in vivo].
Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1969H L, Hahn, D, Henschler
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