Results 81 to 90 of about 333,395 (110)

A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase. [PDF]

BMC Pharmacol Toxicol, 2018
Kuca K, Musilek K, Jun D, Zdarova-Karasova J, Nepovimova E, Soukup O, Hrabinova M, Mikler J, Franca TCC, Da Cunha EFF, De Castro AA, Valis M, Ramalho TC.   +12 more
europepmc   +1 more source

Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon. [PDF]

Molecules, 2018
Kuca K, Jun D, Junova L, Musilek K, Hrabinova M, da Silva JAV, Ramalho TC, Valko M, Wu Q, Nepovimova E, França TCC.   +10 more
europepmc   +1 more source

Human CYP2C9 Metabolism of Organophosphorus Pesticides and Nerve Agent Surrogates. [PDF]

J Xenobiot
Shriwas P, Noonchester AM, Revnew A, Lane TR, Hadad CM, Ekins S, McElroy CA.   +6 more
europepmc   +1 more source

Supramolecular Solid Complexes between Bis-pyridinium-4-oxime and Distinctive Cyanoiron Platforms. [PDF]

Molecules
Picek I, Matković-Čalogović D, Dražić G, Kapun G, Šket P, Popović J, Foretić B.   +6 more
europepmc   +1 more source

Structure-activity studies of bispyridinium antinicotinics to select candidates to treat soman intoxication as part of a combined therapy. [PDF]

PLoS One
Turner SR, Timperley CM, Bird M, Green AC, Price ME, Rice H, Chad JE, Tattersall JEH.   +7 more
europepmc   +1 more source

Spectrophotometric determination of obidoxime chloride as its Pd(II) complex in water and injections

Journal of Pharmaceutical and Biomedical Analysis, 1987
It has been established that obidoxime chloride reacts with palladium(II) chloride in the pH range 3.9-8.0 and forms a yellow water-soluble (1:1) complex with maximum absorbance at 355 nm. By applying the methods of Sommer, Nash and Job involving non-equimolar solutions the conditional stability constant of the complex, at the optimum pH of 6.3 and an ...
Karljiković-Rajić, Katarina, Stanković, B, Binenfeld, Z.J.   +2 more
exaly   +6 more sources

Efficacy of atropine sulfate/obidoxime chloride co-formulation against sarin exposure in guinea pigs

Chemico-Biological Interactions, 2018
The efficacy and pharmacokinetics of the aqueous co-formulation contents of the Trobigard™ (atropine sulfate, obidoxime chloride) auto-injector were evaluated in a sarin exposed guinea pig model. Two subcutaneous (sc) sarin challenge doses were evaluated in guinea pigs instrumented with brain and heart electrodes for electroencephalogram (EEG) and ...
Alex Cornelissen, Marloes Joosen, Mario H Skiadopoulos   +2 more
exaly   +5 more sources

pH-metric investigation of the system containing palladium(II) ion and obidoxime chloride

, 1997
The formation of a complex between palladium (II) chloride obidoxime chloride has been studied by means of pH-metric measurements. Thee mean value of the real stability constant of the complex in aqueous medium of ionic strengths 0.55 M and 1.0 M (KCl) at 298 K was log K-S = 6.72.
Karljiković-Rajić, Katarina, Rajković, MB   +1 more
core   +10 more sources

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Effects of obidoxime chloride on native and sarin-poisoned frog neuromuscular junctions

Pflugers Archiv European Journal of Physiology, 1984
The effect of the oxime reactivator obidoxime chloride (obidoxime) on single frog neuromuscular junctions has been studied in order to clarify its action on the acetylcholine receptor (AChR) and on the acetylcholine esterase (AChE), both before and after blocking its enzymatic activity with the organophosphorus compound sarin. Experiments iontophoretic
C G Caratsch, P G Waser
exaly   +3 more sources

Development of an obidoxime chloride reference material: a metrological approach to the determination of chromatographic purity

Accreditation and Quality Assurance, 2007
A metrological approach to determination of the chromatographic purity of obidoxime chloride and the corresponding obidoxime chloride reference material (RM) with a certified chromatographic purity value have been developed. This value was defined as the ratio of the sum of peak areas of obidoxime chloride isomers to the total peak area of detected ...
Ilya Kuselman
exaly   +2 more sources