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Trauma-toxicology: concepts, causes, complications. [PDF]
Naunyn Schmiedebergs Arch PharmacolBarth H +4 more
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Effects of obidoxime chloride on native and sarin-poisoned frog neuromuscular junctions
Pfl�gers Archiv European Journal of Physiology, 1984The effect of the oxime reactivator obidoxime chloride (obidoxime) on single frog neuromuscular junctions has been studied in order to clarify its action on the acetylcholine receptor (AChR) and on the acetylcholine esterase (AChE), both before and after blocking its enzymatic activity with the organophosphorus compound sarin. Experiments iontophoretic
C G, Caratsch, P G, Waser
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Archives of Toxicology, 2007
The hydrolysis of acetylthiocholine iodide (ATCh) by pralidoxime chloride (2-PAM Cl), trimedoxime (TMB(4)) and obidoxime chlpride (LUH(6)) was studied at pH 5.8-8.0 and incubation temperature from 5 to 40 degrees C in vitro. Significant ATCh hydrolysis by 2-PAM Cl, TMB(4) and LUH(6) was found, with the exceptions of those at pH 7.0, 6.2 and 5.8 at 5 ...
Yi Hui, Zhang +4 more
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The hydrolysis of acetylthiocholine iodide (ATCh) by pralidoxime chloride (2-PAM Cl), trimedoxime (TMB(4)) and obidoxime chlpride (LUH(6)) was studied at pH 5.8-8.0 and incubation temperature from 5 to 40 degrees C in vitro. Significant ATCh hydrolysis by 2-PAM Cl, TMB(4) and LUH(6) was found, with the exceptions of those at pH 7.0, 6.2 and 5.8 at 5 ...
Yi Hui, Zhang +4 more
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Spectrophotometric determination of obidoxime chloride as its Pd(II) complex in water and injections
Journal of Pharmaceutical and Biomedical Analysis, 1987It has been established that obidoxime chloride reacts with palladium(II) chloride in the pH range 3.9-8.0 and forms a yellow water-soluble (1:1) complex with maximum absorbance at 355 nm. By applying the methods of Sommer, Nash and Job involving non-equimolar solutions the conditional stability constant of the complex, at the optimum pH of 6.3 and an ...
Karljiković-Rajić, Katarina +2 more
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Efficacy of atropine sulfate/obidoxime chloride co-formulation against sarin exposure in guinea pigs
Chemico-Biological Interactions, 2018The efficacy and pharmacokinetics of the aqueous co-formulation contents of the Trobigard™ (atropine sulfate, obidoxime chloride) auto-injector were evaluated in a sarin exposed guinea pig model. Two subcutaneous (sc) sarin challenge doses were evaluated in guinea pigs instrumented with brain and heart electrodes for electroencephalogram (EEG) and ...
Marloes J.A. Joosen +7 more
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Accreditation and Quality Assurance, 2007
A metrological approach to determination of the chromatographic purity of obidoxime chloride and the corresponding obidoxime chloride reference material (RM) with a certified chromatographic purity value have been developed. This value was defined as the ratio of the sum of peak areas of obidoxime chloride isomers to the total peak area of detected ...
Ilana Schumacher +3 more
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A metrological approach to determination of the chromatographic purity of obidoxime chloride and the corresponding obidoxime chloride reference material (RM) with a certified chromatographic purity value have been developed. This value was defined as the ratio of the sum of peak areas of obidoxime chloride isomers to the total peak area of detected ...
Ilana Schumacher +3 more
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PDA Journal of Pharmaceutical Science and Technology
Obidoxime chloride is an antidote for nerve gas intoxication. As an emergency medicine, it is being stored by the Israel Defense Forces (IDF) scattered throughout Israel in depots without a controlled environment (field conditions), thus being exposed to high and fluctuating temperatures. These conditions do not meet the manufacturer's requirements. In
Constantin, Itin +2 more
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Obidoxime chloride is an antidote for nerve gas intoxication. As an emergency medicine, it is being stored by the Israel Defense Forces (IDF) scattered throughout Israel in depots without a controlled environment (field conditions), thus being exposed to high and fluctuating temperatures. These conditions do not meet the manufacturer's requirements. In
Constantin, Itin +2 more
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pH-metric investigation of the system containing palladium(II) ion and obidoxime chloride
1997The formation of a complex between palladium (II) chloride obidoxime chloride has been studied by means of pH-metric measurements. Thee mean value of the real stability constant of the complex in aqueous medium of ionic strengths 0.55 M and 1.0 M (KCl) at 298 K was log K-S = 6.72.
Karljiković-Rajić, Katarina +1 more
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