Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates. [PDF]
J Enzyme Inhib Med Chem, 2021 Lee HM +13 more
europepmc +3 more sources
Cholinergic syndrome: a case report of acute organophosphate and carbamate poisoning. [PDF]
Arh Hig Rada Toksikol, 2020 Cholinergic syndrome is a common topic at western medical universities yet rarely observed in clinical practice. The treatment involves muscarinic antagonists, acetylcholinesterase reactivation, seizure control, and supportive measures.
Petreski T +4 more
europepmc +3 more sources
A complete, evidence-based review on novichok poisoning based on epidemiological aspects and clinical management. [PDF]
Front Toxicol, 2022 Background: The whole world has learned about the existence of a highly toxic neuro-paralytic substance called Novichok. A wide range of neuro-paralytic toxins were used during the wars of decades ago, which also had harmful and irreversible effects ...
Charejoo A +3 more
europepmc +3 more sources
Vibrational analysis of 1-methyl-pyridinium-2-aldoxime- and 1-methyl-pyridinium-4-aldoxime chloride [PDF]
, 2011 Pyrimidinium aldoximes are administered in cases of acute organophosphate poisoning. Since questions regarding their morphology and active conformation in the solid state are still open, an effort was made to establish correspondence between their ...
Foretić, Blaženka +2 more
core +1 more source
Recent Development of Nanoparticle Platforms for Organophosphate Nerve Agent Detoxification. [PDF]
LangmuirPoisoning by organophosphate (OP) nerve agents remains a pressing global threat due to their extensive use in chemical warfare agents and pesticides, potentially causing high morbidity and mortality worldwide.
Feng K +7 more
europepmc +3 more sources
Kvalitativna procjena eliminacije TCP-a i TAMORF-a iz organizma štakora metodom GC-MS [PDF]
, 2010 Nerve agents are highly toxic organophosphorus (OP) compounds. They inhibit acetylcholinesterase (AChE), an enzyme that hydrolyses acetycholine (ACh) in the nervous system.
A. Lucić Vrdoljak +20 more
core +2 more sources
Nanochanneled Device and Related Methods [PDF]
, 2013 A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device.
Ferrari, Mauro +7 more
core +5 more sources
Tuning Butyrylcholinesterase Inactivation and Reactivation by Polymer‐Based Protein Engineering
Advanced Science, Volume 7, Issue 1, January 8, 2020., 2020 Butyrylcholinesterase (BChE)‐polymer‐oxime conjugates are synthesized by in situ atom transfer radical polymerization and azide‐alkyne “click” chemistry. The conjugate's activity depends on the electrostatic properties of the polymers and the oxime to BChE ratio.
Libin Zhang +7 more
wiley +1 more source
Cyclosarin-An Organophosphate Nerve Agent [PDF]
, 2005 Organophosphorus compounds ascribed to as nerve agents (sarin, soman, tabun, cyclosarin) are highly toxic, and are considered to be the most dangerous chemical compounds.
Krejcova, G., Kuca, K., Sevelova, L.
core +2 more sources
Nanoparticulate Transport of Oximes over an In Vitro Blood-Brain Barrier Model [PDF]
, 2010 Background: Due to the use of organophosphates (OP) as pesticides and the availability of OP-type nerve agents, an effective medical treatment for OP poisonings is still a challenging problem.
Bungert, Judith +9 more
core +7 more sources