Therapeutic and toxic blood concentrations of nearly 1,000 drugs and other xenobiotics [PDF]
, 2012 Introduction: In order to assess the significance of drug levels measured in intensive care medicine, clinical and forensic toxicology, as well as for therapeutic drug monitoring, it is essential that a comprehensive collection of data is readily ...
Andresen, Hilke +3 more
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The Experimental Oxime K027—A Promising Protector From Organophosphate Pesticide Poisoning. A Review Comparing K027, K048, Pralidoxime, and Obidoxime [PDF]
, 2019 Poisoning with organophosphorus compounds (OPCs) is a major problem worldwide. Standard therapy with atropine and established oxime-type enzyme reactivators (pralidoxime, obidoxime) is unsatisfactory.
Dietrich E. Lorke +2 more
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Intermediate syndrome in organophosphate poisoning: case series [PDF]
, 2017 Acute organophosphate insecticide poisoning is very common in developing countries and the mortality is high because of lack of adequate hospitalization, inadequate atropinization and undiagnosed intermediate syndrome which occur within 24-96 hour after ...
Ochieng, I.A., Saini, P.C.
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Allosteric Modulation of Muscarinic Acetylcholine Receptors [PDF]
, 2007 Muscarinic acetylcholine receptors (mAChRs) are prototypical Family A G protein coupled-receptors. The five mAChR subtypes are widespread throughout the periphery and the central nervous system and, accordingly, are widely involved in a variety of both ...
Christopoulos, Arthur +2 more
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The Mechanism by Which Oximes Reactivate Cholinesterases Inhibited by Organophosphates [PDF]
, 2013 The enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are inhibited by nerve agents such as sarin and tabun. In general, the inhibited enzymes are reactivated by bisquaternary ammonium compounds (oximes).
Bhavaraju, Manikanthan Hari Naga Venkata
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Advances in toxicology and medical treatment of chemical warfare nerve agents [PDF]
, 2012 Organophosphorous (OP) Nerve agents (NAs) are known as the deadliest chemical warfare agents. They are divided into two classes of G and V agents. Most of them are liquid at room temperature.
Emadodin Darchini-Maragheh +2 more
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Characterization of cholinesterase activities for pesticide exposure in food animals [PDF]
, 2012 The primary aim of the work described in this thesis is to establish a foundation for the applicability of a biochemical biomarker, cholinesterase (ChE) activity in food animal species, as an instrument for evaluating exposure to pollutants as well as ...
Abass Askar, Kasim Sakran
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Preparation of Oxime HI-6 (Dichloride and Dimethanesulphonate)ŒAntidote against Nerve Agents [PDF]
, 2008 Because of the threat of misuse of nerve agents as terroristic weapons by the terrorists, animmediate need is felt for the preparation of antidotes on large-scale basis.
Dolezal, Bohumil +5 more
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Acetylcholinesterase Reactivators Antagonize Epileptiform ~u r a i n g Induced by Paraoxon in ~u i n e a Pig Hippocampal Slices [PDF]
, 2020 The electrophysldoglcal actions of paraoxon, an irreversible blocker of acetylcholinesterase, and their antagonism by a series of organophosphate cholinesterase reactivators, were studied in area CAI of the guinea pig hippocampus in vitro.
&apos +5 more
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Pralidoxime –melatonin hybrids as antidotes for chemical poisoning [PDF]
, 2023 Despite the prohibition onthe use, synthesis and storingof Organophosphorus Nerve Agents (OPNA)as Chemical weapons (CW)by the Chemical Weapons Convention(CWC), there are still a lot of organophosphorus compounds being intentionally used for ...
Alonso Gómez, Marta
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