Results 111 to 120 of about 99,866 (311)

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

ABNORMAL VASCULAR REACTIVITY IN THE ob/ob MOUSE [PDF]

Anesthesiology, 2000
B. D. Winters, D. E. Berkowitz, A. A. Shoukas   +2 more
openaire   +1 more source

LncRNA FLJ20021 Restrains Fibroblast Senescence and Matrix Remodeling in Pelvic Organ Prolapse by Promoting XRCC6‐Dependent ADI1 Transcription

Advanced Science, EarlyView.
FLJ20021 interacts with XRCC6 to regulate ADI1 transcription and downstream cellular phenotypes in hUSLFs. Reduced FLJ20021 in POP is associated with lower ADI1, increased apoptosis, senescence, and an ECM‐degrading marker profile. Conversely, FLJ20021 overexpression enhances XRCC6‐dependent ADI1 expression, reduces apoptosis and senescence, and shifts
YanFeng Yang, BingJie Rui, GuangHai Rui, YiNan Duan, Ji Hyang Kim   +4 more
wiley   +1 more source

Association between oxidative balance scores and peripheral artery disease in US adults: a cross-sectional study

Frontiers in Nutrition
BackgroundThe Oxidative Balance Score (OBS) quantifies the overall oxidative stress burden, with higher scores indicating greater antioxidant (relative to prooxidant) activity.
Min Zhou, Min Zhou, Peng-Fei He, Peng-Fei He, Keren Zhang, Li-Juan Deng, Ning Wang, Gang Wang, Guang-Yao Yang, Shang Ju   +9 more
doaj   +1 more source

BRCA1 Mutation‐Recognizing Tetrahedral Framework Nucleic Acid Nanoplatform Enables Coordinated PARP/WEE1 Inhibition and STING‐Associated Antitumor Immunity in Ovarian Cancer

Advanced Science, EarlyView.
BRCA1 mutation‐responsive FBOA‐tFNA selectively recognizes mutant transcripts and coordinates reduction‐responsive intracellular delivery of olaparib and adavosertib, amplifying DNA damage and weakening G2/M checkpoint protection. These effects are accompanied by STING‐associated immune activation and stronger antitumor immunity, while sequential anti ...
Chenyi Wang, Mengying Yao, Jinhui Xie, Dingjie Wang, Yashi Shi, Xiaodan Mao, Chunhua Lu, Pengming Sun   +7 more
wiley   +1 more source

Clinicopathological Study of Patients Presenting with Adnexal Masses

Journal of Rawalpindi Medical College, 2019
Background: To assess the clinicopathological outcome of women with adnexal masses . Method: In this observational study patients with a diagnosis of adnexal mass, who underwent laparotomy, were included.
Asma Batool, Attiya Begum, Sobia Nawaz
doaj  

Four Years Maternal Missed Mortality Ratio and Mortality Index at A Tertiary  Care Hospital in Azad Kashmir

Pakistan Armed Forces Medical Journal
Objective: To calculate the Maternal Near Miss Mortality Ratio and Mortality Index at a tertiary care hospital in a developing country with limited healthcare resources. Study Design: Retrospective analytical study.
Ambreen Ehsan, Maryam Zubair, Abida Islam, Amera Tariq, Umairah Yaqub, Nosheena Shabbir   +5 more
doaj   +1 more source

Single‐Cell Insights Into Pathogenic Profile of Orchitis and SREBP2‐Associated Cholesterol Dysregulation in Spermatogenic Failure

Advanced Science, EarlyView.
A first single‐cell atlas of human orchitis reveals coordinated germ‐cell loss, somatic niche dysfunction, and immune‐metabolic remodeling. Aberrant SREBP2 activation in testicular somatic cells emerges as a central pathogenic node, while Fatostatin‐mediated inhibition of the SREBP pathway improves spermatogenesis, fibrosis, and lipid accumulation in a
Yanlin Tang, Qiaoling Jiang, Yuwen Liu, Wenxiu Zhang, Lina Cui, Xiaojian Lu, Ziyan Zhuang, Jianxing Cheng, Songzhan Gao, Yangyi Fang, Kai Hong, Jie Qiao, Xiaoyan Wang, Hui Jiang, Zhe Zhang, Jingtao Guo, Qiang Liu   +16 more
wiley   +1 more source

Evaluating OBS by effective utilization

, 2013
In optical burst switching (OBS) networks, bursts may be dumped before they reach their destinations due to contention. Accordingly, we classify trunk utilization into effective and ineffective utilizations used for bursts that reach and do not reach ...
Shuo Li (18028678), Eric Wong (14748), Moshe Zukerman (19008206), Meiqian Wang (13004274)   +3 more
core  

CERVICAL CERCLAGE

Journal of Nepal Medical Association, 2003
A Rana, G Gurung, M singh, N Pradhan, R Jha   +4 more
doaj   +1 more source