Results 151 to 160 of about 740,500 (344)

Critical Observation on Methodologies of Select Doctoral Research Studies

, 2014
Goswami
openalex   +1 more source

Towards a Best Practice for Developing Best Practices in Ocean Observation (BP4BP): Supporting Methodological Evolution through Actionable Documentation, [PDF]

, 2020
Cora Hörstmann, Pier Luigi Buttigieg, Pauline Simpson, Jay Pearlman, Johannes Karstensen, Anya M. Waite   +5 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Development of experimental methodology on fracture toughness of microscale polymer resins under in situ observation [PDF]

, 2019
Ryota KANEKO, E. Kaneko, Takashi Sumigawa, Takayuki Kitamura   +3 more
openalex   +1 more source

Methodologic issues regarding background mortality in observational studies [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2011
Osnabrugge, Ruben, Head, Stuart, Kappetein, Arie-Pieter   +2 more
openaire   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

METHODOLOGICAL ASPECT OF OBSERVATION OF CHANGES IN RADON VOLUME CONCENTRATION DEPENDING ON GEOGRAPHIC AND SEISMIC PARAMETERS IN THE REGION

, 2022
Olexiy Smirnov, Mykhailo Muntyan, A. Gubanova, Serhiy Optasiuk   +3 more
openalex   +1 more source

Process and Methodological Considerations for Observational Analyses of Vector Control Interventions in Sub-Saharan Africa Using Routine Malaria Data [PDF]

, 2023
Sarah Burnett, Kelly Davis, Gudissa Assefa, Christelle Gogue, Levi D. Hinneh, Megan Littrell, Julia Mwesigwa, Okefu Oyale Okoko, Saraha Rabeherisoa, Musa Sillah-Kanu, William Sheahan, Hannah Slater, Perpetua Uhomoibhi, Frederick Yamba, Kelley Ambrose, Kathryn Stillman   +15 more
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source