Results 121 to 130 of about 516,287 (323)

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Locating hyperfunctioning parathyroid glands using ¹¹C-Choline PET/CT: an inter- and intra-observer variation study. [PDF]

Eur J Hybrid Imaging, 2021
Christensen JW, Jensen LT, Søndergaard SB, Broholm R, Haarmark C, Krakauer M, Bennedbæk FN, Zerahn B, Trolle W, Hahn CH, Kristensen B.   +10 more
europepmc   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Correspondence: Are Automated Blood Pressure Apparatus Reliable? Automated Versus Manual Measurement of Blood Pressure [PDF]

Journal of Clinical and Diagnostic Research, 2018
Himel Mondal, Shaikat Mondal
doaj   +1 more source

Inter-Observer Variation in Delineating the Pharyngeal Constrictor Muscle as Organ at Risk in Radiotherapy for Head and Neck Cancer. [PDF]

Front Oncol, 2021
Petkar I, McQuaid D, Dunlop A, Tyler J, Hall E, Nutting C.   +5 more
europepmc   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Comparing intra-observer variation and external variations of a fully automated cephalometric analysis with a cascade convolutional neural net. [PDF]

Sci Rep, 2021
Kim IH, Kim YG, Kim S, Park JW, Kim N.
europepmc   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Reproducibility of rCBV in glioblastomas using T2*-weighted perfusion MRI: an evaluation of sampling, normalization, and experience

Diagnostic and Interventional Radiology
PURPOSEThe reproducibility of relative cerebral blood volume (rCBV) measurements among readers with different levels of experience is a concern. This study aimed to investigate the inter-reader reproducibility of rCBV measurement of glioblastomas using ...
Sabahattin Yüzkan, Samet Mutlu, Mehmet Karagülle, Merve Şam Özdemir, Hamit Özgül, Mehmet Ali Arıkan, Burak Koçak   +6 more
doaj   +1 more source

Transformer-Based HER2 Scoring in Breast Cancer: Comparative Performance of a Foundation and a Lightweight Model

Diagnostics
Background/Objectives: Human epidermal growth factor 2 (HER2) scoring is critical for modern breast cancer therapies, especially with emerging indications of antibody–drug conjugates for HER2-low tumors.
Yeh-Han Wang, Min-Hsiang Chang, Hsin-Hsiu Tsai, Chun-Jui Chien, Jian-Chiao Wang   +4 more
doaj   +1 more source