Results 81 to 90 of about 670,138 (315)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

The importance of the occupational vocal load for the occurence and treatment of organic voice disorders

open access: yesSlovenian Journal of Public Health, 2018
The voice represents a basic working tool for carrying out certain occupations. Hoarseness, as a consequence of vocal fold lesions, presents an important cause of work-related absences for voice professionals.
Zabret Miha   +2 more
doaj   +1 more source

On the Sorting of Physicians across Medical Occupations [PDF]

open access: yes
We model the sorting of medical students across medical occupations and identify a mechanism that explains the possibility of differential productivity across occupations.
Courty, Pascal, Marschke, Gerald
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

“Ocupar de novo para defender o que é nosso”: a histórica resistência às barragens da comunidade rural Casa Nova, Guaraciaba-MG / “Reoccupy to defend what is ours”: the historical resistance to dams of the Casa Nova rural community, Guaraciaba, Minas Gerais (Brazil) [PDF]

open access: yesSociedade & Natureza, 2013
This article examines the occupations as a form of struggle and resistance of a rural community affectedby hydroelectric plants on the river basin of the Piranga river, in the county of Guaraciaba, southeast ofMinas Gerais.
Aline Guizardi Delesposte, Lucas Magno
doaj  

Employment and Wages in Community and Social Service Occupations [PDF]

open access: yes, 2012
People who work in community and social service occupations are concerned with improving society and the lives of individuals. These workers perform a diverse array of duties that may include counseling individuals with substance abuse and behavioral ...
Jones, John I
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Early Portuguese Data for Wage Developments in India: Kannur (Cananor), 1516-1517

open access: yesLer História, 2019
This essay discusses new evidence for wage developments in Western India from c. 1300 to 1600. By introducing wage and price data for Kannur (Cananor in Portuguese and British sources) for the years 1516-1517 we contribute to a larger discussion about ...
Paulo Teodoro de Matos, Jan Lucassen
doaj   +1 more source

An Overview of U.S. Occupational Employment and Wages in 2011 [PDF]

open access: yes, 2012
A substantial share of U.S. employment in May 2011 was concentrated in a relatively small number of occupations. Just 10 occupations made up more than 20 percent of total employment, and the 20 largest occupations made up nearly one-third of employment ...
Watson, Audrey
core   +1 more source

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