Results 41 to 50 of about 2,646 (192)
Metabolites, 2022 Changes in the phenylalanine (PHE)/tyrosine (TYR) pathway metabolites before and during homogentisic acid (HGA)-lowering by nitisinone in the Suitability of Nitisinone in Alkaptonuria (AKU) 2 (SONIA 2) study enabled the magnitude of the flux in the ...
Lakshminarayan R. Ranganath +10 more
doaj +1 more source
КардиоСоматикаBACKGROUND: Ochronosis is a rare disorder caused by an inherited defect in tyrosine metabolism, in which the biochemical degradation pathway is interrupted at the stage of homogentisic acid formation.
Amina M. Alieva +6 more
doaj +1 more source
Exogenous ochronosis after prolonged use of topical hydroquinone (2%) in a 50-year-old Indian female
Indian Journal of Dermatology, 2012 Ochronosis is a rare disease characterized by speckled and diffuse pigmentation symmetrically over the face, neck, and photo-exposed areas. It is characterized histologically by banana-shaped ochre-colored deposits in the dermis.
Vijay Gandhi +2 more
doaj +1 more source
Utilizing fractional resurfacing in the treatment of therapy‐resistant melasma [PDF]
, 2005 Background. Multiple treatment modalities have been employed for the management of melasma with minimal to no success. Objective. We propose fractional resurfacing as a new treatment modality for melasma. Methods.
Tannous, Zeina S.
core +1 more source
Case report: hydroquinone and/or glutaraldehyde induced acute myeloid leukaemia? [PDF]
, 2006 Background Exposures to high doses of irradiation, to chemotherapy, benzene, petroleum products, paints, embalming fluids, ethylene oxide, herbicides, pesticides, and smoking have been associated with an increased risk of acute myelogenous leukemia (AML).
Alexopoulos Evangelos C +1 more
core +2 more sources
Case Report: Ochronotic Arthropathy
Forbes Tıp Dergisi, 2021 Ochronosis is a rare metabolic disease caused by the deficiency of the homogentisic acid oxidase enzyme. It gives clinical findings related to the accumulation of homogentisic acid in soft tissues and excretion in urine. Patients with chronic arthropathy
Ülkü Dönmez +3 more
doaj +1 more source
Knee degenerative osteoarthritis secondary to ochronosis (case report)
Travmatologiâ i Ortopediâ Rossii, 2013 Alkaptonuria is rare disease with deficiency of homogentisate-1,2-dioxygenase enzyme, resulting in excess deposition of homogentisic acid in connective tissue. This deposition leads to ochronosis - brownish-black pigmentation of connective tissue.
V. V. Bliznyukov +2 more
doaj +1 more source
Okronotik Artropati: Sementsiz Total Diz Artroplastisi Uygulaması
Ankara Üniversitesi Tıp Fakültesi Mecmuası, 2010 Alkaptonuria is an autozomal recessive metabolic disease that goes with the deficiency of homo-gentisic acid oxidase. Collection of the metabolits of HGA in connective tissues results ochronosis.
Emrah Sayıt, Hakan Aslan, Erbil Aydın
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Anais Brasileiros de Dermatologia, 2012 Exogenous ochronosis is a rare, cosmetically disfiguring condition, resulting from the longterm use of topical hydroquinone in treatment of melasma. It manifests as gray-brown or blue-black macules in hydroquinone-exposed regions.
Viviane Maria Rocha Martins +5 more
doaj +1 more source
Orthopaedic Surgery, EarlyView.Arthroscopic microfracture combined with autologous collagen‐induced chondrogenesis provides superior long‐term cartilage regeneration and sustained clinical improvement in knee cartilage defects, as evidenced by 5‐year MRI and functional outcomes. ABSTRACT Objectives Cartilage defect of the knee joint is a common cause of knee pain and can result in ...
Shuofang Ren +8 more
wiley +1 more source