Results 61 to 70 of about 2,646 (192)
Dermatologic Therapy, Volume 2026, Issue 1, 2026.Background Melasma treatment remains challenging with variable response to conventional lightening agents. Polyamine inhibition via ornithine decarboxylase 1 (ODC1) may offer an alternative approach, with eflornithine hydrochloride being an established ODC1 inhibitor. Objectives To compare the efficacy and safety of eflornithine hydrochloride 13% cream
Jonathan Yongwei Boey +7 more
wiley +1 more source
Ochronotic arthropathy, an approach to osteoarthritis bone remodelling [PDF]
, 2018 The objective is to use hip ochronotic arthropathy for an indirect approach to osteoarthritis bone remodelling in a human joint via an identified causal chondropathy.
Lagier, René
core
High Prevalence of Skin Disorders among HTLV-1\ud Infected Individuals Independent of Clinical Status [PDF]
, 2013 Background\ud Human T-cell lymphotropic virus type 1 (HTLV-1) infection can increase the risk of developing skin disorders. This study evaluated the correlation between HTLV-1 proviral load and CD4+ and CD8+ T cells count among HTLV-1 infected ...
Casseb, Jorge Simão do Rosário +4 more
core +3 more sources
Alkaptonuric patient presenting with “black” disc: a case report
Acta Orthopaedica et Traumatologica Turcica, 2020 Although intervertebral disc degeneration usually occurs in the natural course of alkaptonuria, detection of the disease by black disc material in a patient without any other sign of alkaptonuria is an extremely rare condition.
Ramazan Kahveci +3 more
doaj +1 more source
Plants from Brazilian cerrado with potent tyrosinase inhibitory activity [PDF]
, 2012 The increased amount of melanin leads to skin disorders such as age spots, freckles, melasma and malignant melanoma. Tyrosinase is known to be the key enzyme in melanin production.
Batista, Pérola de Oliveira Magalhães Dias +9 more
core +2 more sources
Patellar ligament rupture during total knee arthroplasty in an ochronotic patient
Acta Orthopaedica et Traumatologica Turcica, 2020 Ochronotic arthropathy mainly involves the spine and large joints. Along with blackening of the joint, degeneration rapidly progresses mostly in the knee, resulting in symptoms by the 4th or 5th decade.
Madan Mohan Sahoo +3 more
doaj +1 more source
Journal of Cosmetic Dermatology, Volume 24, Issue 10, October 2025.ABSTRACT Introduction Melasma is a chronic refractory pigmentation disorder. Kligman triple (KT) formula is the gold standard. A dermocosmetic (DC) serum containing vitamin B3 and 2‐mercaptonicotinyl glycine has been developed for melasma. This study assessed the benefits of DC serum compared to KT in melasma.
Juliane Rocio +7 more
wiley +1 more source
Inborn errors of metabolism: a clinical overview [PDF]
, 1999 CONTEXT: Inborn errors of metabolism cause hereditary metabolic diseases (HMD) and classically they result from the lack of activity of one or more specific enzymes or defects in the transportation of proteins.
Martins, Ana Maria
core +4 more sources
Ochronotic Chronic Tendoachilles Rupture Management: A Case Series [PDF]
Journal of Foot and Ankle Surgery (Asia Pacific)Background: Alkaptonuria is a rare inherited genetic disorder in which there is a deficiency of the enzyme homogentisate 1,2-dioxygenase. The three characteristics of alkaptonuria are homogentisic-aciduria, ochronosis, and ochronotic arthropathy ...
Jeremy B Dorai, Issac Jebaraj
doaj +1 more source
Descemet’s membrane folds in ochronosis: a case report
Journal of Medical Case Reports, 2022 Background We present this report of a new ophthalmic finding in a patient with ochronosis. Case presentation An 85-year-old Caucasian male patient with bilateral dark temporal and nasal pigmentation of conjunctiva and sclera was referred to our hospital
Otavio de Azevedo Magalhaes +1 more
doaj +1 more source