Results 61 to 70 of about 919 (164)

The trajectory of vesicular proteomic signatures from HBV‐HCC by chitosan‐magnetic bead‐based separation and DIA‐proteomic analysis

Journal of Extracellular Vesicles, Volume 13, Issue 9, September 2024.
Abstract Hepatocellular carcinoma (HCC) is a prevalent primary liver cancer often associated with chronic hepatitis B virus infection (CHB) and liver cirrhosis (LC), underscoring the critical need for biomarker discovery to improve patient outcomes. Emerging as a promising avenue for biomarker development, proteomic technology leveraging liquid biopsy ...
Lin Cao, Yue Zhou, Shuai Lin, Chunyan Yang, Zixuan Guan, Xiaofan Li, Shujie Yang, Tong Gao, Jiazhen Zhao, Ning Fan, Yanan Song, Dongmin Li, Xiang Li, Zhuo Li, Feng Guan, Zengqi Tan   +15 more
wiley   +1 more source

Intravitreal ocriplasmin for the treatment of vitreomacular traction and macular hole- A study of efficacy and safety based on NICE guidance.

PLoS ONE, 2018
PurposeTo evaluate the real world clinical outcomes of intravitreal ocriplasmin in patients with vitreomacular traction (VMT) with and without full thickness macular holes (FTMH) treated according to NICE guidance.MethodsRetrospective observational case ...
Mahiul M K Muqit, Robin Hamilton, Jason Ho, Sally Tucker, Helen Buck   +4 more
doaj   +1 more source

Identification of the circRNA–miRNA–mRNA regulatory network in osteoarthritis using bioinformatics analysis

Frontiers in Genetics, 2022
Background: Osteoarthritis (OA) is a degenerative joint disease that seriously affects the quality of people. Unfortunately, the pathogenesis of OA has not been fully known.
Wen-Bin Xu, Vit Kotheeranurak, Vit Kotheeranurak, Huang-Lin Zhang, Jin-Yi Feng, Jing-Wei Liu, Chien-Min Chen, Chien-Min Chen, Chien-Min Chen, Guang-Xun Lin, Guang-Xun Lin, Gang Rui, Gang Rui   +12 more
doaj   +1 more source

Network‐based identification of key proteins and repositioning of drugs for non‐small cell lung cancer

Cancer Reports, Volume 7, Issue 4, April 2024.
Abstract Background NSCLC is a lethal cancer that is highly prevalent and accounts for 85% of cases of lung cancer. Conventional cancer treatments, such as chemotherapy and radiation, frequently exhibit limited efficacy and notable adverse reactions. Therefore, a drug repurposing method is proposed for effective NSCLC treatment. Aims This study aims to
Oluwatosin Maryam Adeyemo, Zainab Ashimiyu‐Abdusalam, Mary Adewunmi, Temitope Ayanfunke Ayano, Muhammad Sohaib, Reem Abdel‐Salam   +5 more
wiley   +1 more source

Initial Outcomes Following Intravitreal Ocriplasmin for Treatment of Symptomatic Vitreomacular Adhesion

, 2013
When delivered via a single intravitreal injection, ocriplasmin can effect proteolytic resolution of symptomatic vitreomacular adhesion (VMA).
Kim, Brian T, Smiddy, William E, Andrew A. Moshfeghi, Kovach, Jaclyn L, Jaclyn L. Kovach, Stephen G. Schwartz, Brian T. Kim, William E. Smiddy, Doshi, Rishi R, Schwartz, Stephen G, Audina M. Berrocal, Moshfeghi, Andrew A, Jorge A. Fortun, Fortun, Jorge A, Berrocal, Audina M, Rishi R. Doshi   +15 more
core   +1 more source

Visual function response to ocriplasmin for the treatment of vitreomacular traction:results from the oasis study [PDF]

, 2016
PurposeThe effect of an intravitreal ocriplasmin-injection on vitreomacular adhesion (VMA) resolution was investigated in a phase 3b randomized, sham-controlled, double-masked, multicentre study. The objective of this analysis was to assess the effect of
Lescrauwaet, B., Duchateau, L., Jackson, T.l.; id_orcid, Verstraeten, T.   +3 more
core   +1 more source

Cost-effectiveness analysis of ocriplasmin versus watchful waiting for treatment of symptomatic vitreomacular adhesion in the US [PDF]

, 2020
Aim: Evaluate the cost-effectiveness of ocriplasmin in symptomatic vitreomacular adhesion (VMA) with or without full-thickness macular hole ≤400 μm versus standard of care.
Lescrauwaet, Benedicte, Dugel, Pravin U, Haller, Julia A, Wagner, Alan L, Schmidt, Ralph, Khanani, Arshad M, Bennison, Craig   +6 more
core   +1 more source

Molecular farming: Expression of recombinant Ocriplasmin in genetically transformed root culture of Nicotiana tabaccum [PDF]

Caspian Journal of Environmental Sciences
Ocriplasmin, also known as microplasmin (JetreaTM), is a novel recombinant drug approved by the FDA. It is a truncated human plasmin used for the treatment of vitreoretinopathies. In the present study, ocriplasmin was expressed in Nicotiana tabacum hairy
Ata Allah Sharafi, Habibollah Samizadeh Lahiji, Ali Sharafi, Farjad Rafeie, Mohammad Javad Motamedi   +4 more
doaj   +1 more source

Comprehensive bioinformatic analysis reveals a cancer-associated fibroblast gene signature as a poor prognostic factor and potential therapeutic target in gastric cancer

BMC Cancer, 2022
Background Gastric cancer is one of the deadliest cancers, currently available therapies have limited success. Cancer-associated fibroblasts (CAFs) are pivotal cells in the stroma of gastric tumors posing a great risk for progression and chemoresistance.
Cemre Ucaryilmaz Metin, Gulnihal Ozcan
doaj   +1 more source

Floaters and reduced contrast sensitivity after successful pharmacologic vitreolysis with ocriplasmin

American Journal of Ophthalmology Case Reports, 2016
Purpose: To describe the onset of floaters and reduction in contrast sensitivity (CS) following successful pharmacologic vitreolysis with ocriplasmin for the treatment of vitreo-macular traction (VMT) in a patient with previously normal CS. Observations:
Matin Khoshnevis, Jeannie Nguyen-Cuu, J. Sebag   +2 more
doaj   +1 more source