Results 71 to 80 of about 796,114 (289)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Ocular Nanomedicine

Advanced Science, 2022
Intrinsic shortcomings associated with conventional therapeutic strategies often compromise treatment efficacy in clinical ophthalmology, prompting the rapid development of versatile alternatives for satisfactory diagnostics and therapeutics.
Zhimin Tang, Xianqun Fan, Yu Chen, Ping Gu   +3 more
doaj   +1 more source

Clinical signs in neuro-ophthalmology: Eye signs in myasthenia gravis

Annals of Indian Academy of Neurology, 2022
A hallmark of myasthenia gravis (MG) is the variability and fatigability of striated muscles. The majority of people with MG have eye symptoms of ptosis and diplopia.
Sui Hsien Wong
doaj   +1 more source

Tear ferning test and pathological effects on ocular surface before and after topical cyclosporine in vernal keratoconjunctivitis patients [PDF]

, 2018
Background: Vernal keratoconjunctivitis (VKC) is a rare ocular surface inflammatory disease that affects mainly boys in the first decade of life.
Bianchi, Guia, Del Regno, Paola, Duse, Marzia, Lambiase, Alessandro, Nebbioso, Marcella, Sacchetti, Marta, Zicari, Anna Maria   +6 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Myopes have significantly higher serum melatonin concentrations than non-myopes [PDF]

, 2017
Purpose Experimental animal models of myopia demonstrate that higher melatonin (Mel) and lower dopamine (DA) concentrations actively promote axial elongation.
Ackermann, Atkinson, Ayaki, Baba, Barnard, Beck-Friis, Benavente-Pérez, Benloucif, Berg, Bertolet, Besharse, Breslin, Brown, Cahill, Chang, Chiba, Chua, Delgado, Dong, Eisenberg, Fan, Freedman, Guo, Hammond, He, Hua, Huang, Huang, Hughes, Iuvone, Jee, Kivelä, Lanyon, Logan, Lu, Mallen, Mao, Martin, McCullough, Megaw, Megaw, Nickla, Nickla, Ohngemach, Panda, Pendrak, Rada, Rao, Riefahn, Rohrer, Rose, Rudnicka, Sankaridurg, Skene, Stone, Stone, Stormann, Tosini, Trier, Verkicharla, Wahl, Wallman, Wang, Weiss, Wiechmann, Wiechmann, Wilson, Witkovsky, Wu, Xu, Zhang   +70 more
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Coordinated optimization of visual cortical maps (II) Numerical studies [PDF]

, 2012
It is an attractive hypothesis that the spatial structure of visual cortical architecture can be explained by the coordinated optimization of multiple visual cortical maps representing orientation preference (OP), ocular dominance (OD), spatial frequency,
A Antonini, A Das, A Grabska-Barwinska, A Grinwald, A Jacobs, A Shmuel, A Soward, A Zepeda, AA Koulakov, AP Bartsch, B Chapman, BA Malomed, BJ Farley, BS Wang, C Blakemore, C Blakemore, C von der Malsburg, CE Giacomantonio, CF Stevens, CJ Shatz, CJ Shatz, CN Levelt, D Bensimon, D Boyer, D Boyer, D Mitchell, D Shulz, DC Johns, DE Mitchell, DE Mitchell, DE Mitchell, DL Adams, DL Adams, DL Ringach, DL Ringach, Dominik Heide, E Bartfeld, E Bodenschatz, E Erwin, E Erwin, EM Slimko, F Wolf, F Wolf, F Wolf, FH Busse, Fred Wolf, GG Blasdel, GG Blasdel, GG Blasdel, GJ Goodhill, H Nakagama, H Ritter, H Wassle, H Yu, HY Lee, HZ Shouval, JA Bednar, JA Bednar, JB Swift, JE Dennis, JR Villablanca, Justin C. Crowley, K Albus, K Lehmann, K Obermayer, K Obermayer, K Obermayer, K Ohki, KD Miller, KD Miller, KD Miller, KR Duffy, KR Jones, L Reichl, L Reichl, Lars Reichl, LE White, LE White, M Argentina, M Cynader, M Hammele, M Hübener, M Imbert, M Kaschube, M Kaschube, M Kaschube, M Kaschube, M Kaschube, M Sato, M Schnabel, M Weliky, MA Carreira-Perpinan, Matthias Kaschube, MC Crair, MC Cross, MW Cho, MW Cho, N Mayer, ND Mermin, NL Rochefort, NP Issa, NV Swindale, NV Swindale, NV Swindale, NV Swindale, NV Swindale, NV Swindale, NW Daw, Olaf Sporns, P Buisseret, P Buisseret, P Coullet, PC Bressloff, PN Brown, R Engelmann, RAW Galuske, RE Soodak, S Grossberg, S LeVay, S Löwel, S Löwel, S Löwel, S Rathjen, S Rathjen, S Schuett, SB Paik, SC Rao, Siegrid Löwel, SJ Espinosa, T Bonhoeffer, T Bonhoeffer, T Bonhoeffer, TN Wiesel, U Ernst, W Keil, W Keil, W Zhang, W Zimmermann, W Zimmermann, WH Bosking, X Xu, Y Diao, Y Fregnac, Y Fregnac, Y Fregnac, Y Kremer, Y Li, Y Li, Y Pomeau, Y Pomeau   +149 more
core   +4 more sources

Ocular dirofilariasis

Indian Journal of Pathology and Microbiology, 2010
Dirofilaria is a parasite of domestic and wild animals that can infect humans accidentally. It is being reported in increasing numbers from Mediterranean countries like Italy. In India this infection is occasionally being reported. We report three cases of ocular dirofilariasis from the state of Assam presenting as periorbital and subconjunctival cysts.
Nath Reema, Gogoi Rajen, Bordoloi Narayan, Gogoi Tapan   +3 more
openaire   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source