Results 41 to 50 of about 49,463 (304)

Breaking barriers: Aptamers in ocular disease treatment

Molecular Therapy: Nucleic Acids
Tao Wang, Rakesh Naduvile Veedu
doaj   +2 more sources

MMP-3 deficiency alleviates endotoxin-induced acute inflammation in the posterior eye segment [PDF]

, 2016
Matrix metalloproteinase-3 (MMP-3) is known to mediate neuroinflammatory processes by activating microglia, disrupting blood-central nervous system barriers and supporting neutrophil influx into the brain. In addition, the posterior part of the eye, more
Becker, Claude Libert, De Vos, Eichler, Evy Lefevere, Fuentes, Gearing, Goureau, Hoekzema, Hoekzema, Inge Van Hove, Jurgen Sergeys, Kaplanski, Kyriakis, Lies De Groef, Lieve Moons, Manuel Salinas-Navarro, Nemzek, Noble, Planck, Roosmarijn Vandenbroucke, Russ, Sudharshan, Suzuki, Tuaillon, Yadav, Zech   +26 more
core   +2 more sources

Therapeutics and carriers: The dual role of proteins in nanoparticles for ocular delivery [PDF]

, 2015
© 2015 Bentham Science Publishers. Blindness and visual impairment affect millions of people worldwide and have a very important impact on patients quality of life.
Nicoli, S, Pescina, S, Santi, P, Sonvico, F   +3 more
core   +1 more source

Sustained gene expression in the retina by improved episomal vectors [PDF]

, 2014
Gene and cellular therapies are nowadays part of therapeutic strategies for the treatment of diverse pathologies. The drawbacks associated with gene therapy-low levels of transgene expression, vector loss during mitosis, and gene silencing-need to be ...
Ana V. Oliveira, Conley S.M., Davis A.A., Gabriela A. Silva, Reinisalo M., Rudolf Haase, Sofia M. Calado, Susana Machado   +7 more
core   +1 more source

Unraveling the Therapeutic Enigma of Liposomes in Ocular Drug Delivery

Journal of Bio-X Research
The ocular delivery of drugs has always presented a pharmaceutical challenge. Various ocular barriers, such as reflex blinking, tear turnover, epithelial tight junctions, metabolism in ocular tissues, efflux pumps, nasolacrimal drainage, and other blood ...
Sandip Karmakar, Sreejan Manna, Tamal Jana, Sougata Jana, Gouranga Nandi   +4 more
doaj   +1 more source

Vitreous: A Barrier to Nonviral Ocular Gene Therapy

Investigative Opthalmology & Visual Science, 2005
Intravitreal injection of therapeutic DNA, complexed to nonviral carriers such as cationic liposomes, may be promising in the treatment of many severe retinal eye diseases. However, after intravitreal injection, such DNA/cationic liposome complexes-called lipoplexes (LPXs)-which are typically hundreds of nanometers in size, must first diffuse through ...
Peeters, Liesbeth, Sanders, Nn., Braeckmans, K., Boussery, K., Van De Voorde, J., De Smedt, Sc., Demeester, J.   +6 more
openaire   +3 more sources

Cognitive Functioning in Vorinostat‐Treated Pediatric and Young Adult Patients Over the First 180 Days After Hematopoietic Stem Cell Transplant

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Cognitive and psychological difficulties could negatively interfere with treatment adherence and quality of life before and after hematopoietic stem cell transplant (HSCT). Methods to mitigate these changes may have positive effects on treatment success.
Kristen L. Votruba, Michelle Rozwadowski, Thomas Braun, April Rahrig, Edward Peres, Kirsten M. Williams, Vanessa Fabrizio, Julie‐An Talano, Carrie L. Kitko, Nicolas Parnell, Pavan Reddy, Sung Won Choi   +11 more
wiley   +1 more source

Mutations in the RB1 Gene in Argentine Retinoblastoma Patients and Uncommon Clinical Presentations [PDF]

, 2015
Background: Retinoblastoma, the most common ocular cancer of childhood, is caused by inactivation of the RB1 tumor suppressor gene in the developing retina.
Alonso, Cristina, Ferrer, Marcela Maria, Giliberto, Florencia, Luce, Leonela Natalia, Ottaviani, Daniela, Parma, Diana Lidia, Szijan, Irena   +6 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Awareness regarding eye donation among stakeholders in Srikakulam district in South India [PDF]

, 2014
Background There is a huge need for the availability of transplantable donor corneas worldwide to reduce the burden of corneal blindness due to corneal opacity.
Jalbert, I., Ramachandran, B. P., Ronanki, V. R., Sheeladevi, S.   +3 more
core   +4 more sources