Is the Conjunctiva a Potential Target for Advanced Therapy Medicinal Products?
Pharmaceutics, 2021 The conjunctiva is a complex ocular tissue that provides mechanical, sensory, and immune protection for the ocular surface. It is affected by many diseases through different pathological mechanisms.
Yolanda Diebold, Laura García-Posadas
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Assessing full thickness oral mucosal grafting: complications and postoperative outcomes in a broad collective of patients [PDF]
, 2020 Background: Conjunctival defects can be repaired with several mucosal tissues. The simplicity of harvesting oral mucosa and its wide availability makes it the preferred graft tissue for all indications requiring mucosal grafting. Through analysing the
Bertelmann, Eckart +2 more
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A stepping stone in treating dendritic keratitis
American Journal of Ophthalmology Case Reports, 2017 Purpose: To report the outcome of self-retained amniotic membrane after debridement in recurrent dendritic keratitis. Observations: A 70-year-old female with a recurrent dendritic corneal ulcer received debridement followed by placement of self-retained ...
Hosam Sheha, MD, PhD +3 more
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Gut-derived butyrate suppresses ocular surface inflammation
Scientific Reports, 2022 Dry eye is a common ocular inflammatory disorder characterized by tear film instability and reduced tear production. There is increasing evidence that homeostasis of the ocular surface is impacted by the intestinal microbiome.
Laura Schaefer +6 more
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Frontiers in Medicine, 2021 Purpose: To conduct a multi-center analysis and assess the economic burden due to dry eye disease (DED) in China.Design: A retrospective and cross-sectional study.Methods: Patients (n = 598) with diagnosed DED were recruited from 3 eye centers (in ...
Wanju Yang +29 more
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Ocular surface evaluation in eyes with chronic glaucoma on long term topical antiglaucoma therapy [PDF]
International Journal of Ophthalmology, 2017 AIM: To evaluate ocular surface changes and its correlation with the central corneal subbasal nerve fibre layer in chronic glaucoma patients. METHODS: A prospective comparative study of ocular surface evaluation was performed in 50 eyes of 25 patients ...
Manu Saini +5 more
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Advanced Therapy Medicinal Products for the Eye: Definitions and Regulatory Framework
Pharmaceutics, 2021 Advanced therapy medicinal products (ATMPs) are a group of innovative and complex biological products for human use that comprises somatic cell therapy medicinal products, tissue engineered products, gene therapy medicinal products, and the so-called ...
Marina López-Paniagua +5 more
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Impacto da poluição ambiental na superfície ocular de pacientes com síndrome de Sjögren [PDF]
, 2018 Purpose: To evaluate the effect of air pollution on the ocular surface of patients with Sjögren's syndrome. Methods: We investigated the ocular surfaces of thirty patients with Sjögren's syndrome and thirty healthy volunteers (control group) living in ...
Berra, Alejandro +5 more
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Toll-like receptor 2-mediated NF-kappa B pathway activation in ocular surface epithelial cells
Eye and Vision, 2017 Background Gram-positive bacteria stimulate Toll-like receptor (TLR) 2 and then activate the pro-inflammatory nuclear factor-kappa B (NF-κB) pathway.
Aihua Hou, Min Qi Tin, Louis Tong
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Therapeutic Effect of Human Adipose Tissue-Derived Mesenchymal Stem Cells in Experimental Corneal Failure Due to Limbal Stem Cell Niche Damage [PDF]
, 2017 Producción CientíficaLimbal stem cells are responsible for the continuous renewal of the corneal epithelium. The destruction or dysfunction of these stem cells or their niche induces limbal stem cell deficiency (LSCD) leading to visual loss, chronic pain,
Calonge Cano, Margarita +7 more
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