Sonic Hedgehog Signaling and Development of the Dentition [PDF]
Journal of Developmental Biology, 2017 Sonic hedgehog (Shh) is an essential signaling peptide required for normal embryonic development. It represents a highly-conserved marker of odontogenesis amongst the toothed vertebrates.
Maisa Seppala +4 more
doaj +3 more sources
Piezo1 Regulates Odontogenesis via a FAM83G-Mediated Mechanism in Dental Papilla Cells In Vitro and In Vivo [PDF]
BiomoleculesThis study explored the role of Piezo1 in the odontogenic differentiation of dental papilla cells (DPCs) and tissue, focusing on a mechanism involving family with sequence similarity 83, member G (FAM83G). Here, we found Piezo1, a mechanosensitive cation
Xinyue Sheng +7 more
doaj +2 more sources
The metamorphic transition of the frog mouth: from tadpole keratinized mouthparts to adult teeth [PDF]
Royal Society Open ScienceTeeth have been a prominent feature of most vertebrates for 400 million years, and the core regulatory network underlying embryonic tooth formation is deeply conserved.
Daniel J. Paluh +6 more
doaj +2 more sources
Cathepsin K‐Positive Cell Lineage Promotes In Situ Dentin Formation Controlled by Nociceptive Sonic Hedgehog [PDF]
Advanced ScienceOral diseases affect nearly half of the global population throughout their lifetime causing pain, as estimated by the World Health Organization. Preservation of vital pulp is the therapeutic core as well as a challenge to protect natural teeth.
Ruoshi Xu +12 more
doaj +2 more sources
Impact of FasL Stimulation on Sclerostin Expression and Osteogenic Profile in IDG-SW3 Osteocytes
Biology, 2021 The Fas ligand (FasL) is known from programmed cell death, the immune system, and recently also from bone homeostasis. As such, Fas signalling is a potential target of anti-osteoporotic treatment based on the induction of osteoclastic cell death.
Adela Kratochvilova +6 more
doaj +1 more source
Ectopic premolar tooth in the sigmoid notch [PDF]
, 2016 Impaction of a mandibular premolar is relatively uncommon. Ectopic placement is more unusual and there has been no discussion in the literature of an ectopic mandibular premolar in the coronoid process. In this case report, we present an impacted ectopic
Akgul, Hayati Murat +2 more
core +13 more sources
Immunomodulation stimulates the innervation of engineered tooth organ [PDF]
, 2014 The sensory innervation of the dental mesenchyme is essential for tooth function and protection. Sensory innervation of the dental pulp is mediated by axons originating from the trigeminal ganglia and is strictly regulated in time. Teeth can develop from
Bécavin, Thibault +5 more
core +17 more sources
Role of Cell Death in Cellular Processes During Odontogenesis
Frontiers in Cell and Developmental Biology, 2021 The development of a tooth germ in a precise size, shape, and position in the jaw, involves meticulous regulation of cell proliferation and cell death.
John Abramyan +5 more
doaj +1 more source
Formation and Developmental Specification of the Odontogenic and Osteogenic Mesenchymes
Frontiers in Cell and Developmental Biology, 2020 Within the mandible, the odontogenic and osteogenic mesenchymes develop in a close proximity and form at about the same time. They both originate from the cranial neural crest. These two condensing ecto-mesenchymes are soon separated from each other by a
Eva Svandova +4 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2023 As the dentition forms and becomes functional, the alveolar bone is remodelled. Metalloproteinases are known to contribute to this process, but new regulators are emerging and their contextualization is challenging.
S. Varadinkova +11 more
doaj +1 more source