Results 61 to 70 of about 49,423 (284)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Plume Dynamics Structure the Spatiotemporal Activity of Mitral/Tufted Cell Networks in the Mouse Olfactory Bulb

Frontiers in Cellular Neuroscience, 2021
Although mice locate resources using turbulent airborne odor plumes, the stochasticity and intermittency of fluctuating plumes create challenges for interpreting odor cues in natural environments.
Suzanne M. Lewis, Lai Xu, Nicola Rigolli, Nicola Rigolli, Mohammad F. Tariq, Lucas M. Suarez, Merav Stern, Agnese Seminara, David H. Gire   +8 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Correlation between Threshold Odor Numbers and the Concentration of Odorous Substances in Water

Water Science and Technology, 1988
The aim of this study was to ascertain the actual correlation between the threshold odour number (TON) and concentration of odorous substances in water. The results showed that the relationship between the TON values and the concentration of off-flavor substances seemed to be appropriately explained by the Stevens Model.
T. Goda, N. Ichikawa, M. Tomita
openaire   +1 more source

Electronic Nose Testing Procedure for the Definition of Minimum Performance Requirements for Environmental Odor Monitoring

Sensors, 2016
Despite initial enthusiasm towards electronic noses and their possible application in different fields, and quite a lot of promising results, several criticalities emerge from most published research studies, and, as a matter of fact, the diffusion of ...
Lidia Eusebio, Laura Capelli, Selena Sironi   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Peripheral Adaptation Codes for High Odor Concentration in Glomeruli [PDF]

The Journal of Neuroscience, 2009
Adaptation is a general property of sensory receptor neurons and has been extensively studied in isolated cell preparation of olfactory receptor neurons. In contrast, little is known about the conditions under which peripheral adaptation occurs in the CNS during odorant stimulation.
Jérôme, Lecoq, Pascale, Tiret, Serge, Charpak   +2 more
openaire   +2 more sources

Odor Sampling: Techniques and Strategies for the Estimation of Odor Emission Rates from Different Source Types

Sensors, 2013
Sampling is one of the main issues pertaining to odor characterization and measurement. The aim of sampling is to obtain representative information on the typical characteristics of an odor source by means of the collection of a suitable volume fraction ...
Renato Del Rosso, Selena Sironi, Laura Capelli   +2 more
doaj   +1 more source

Investigação do limite de percepção olfativa por olfatometria e por cromotografia gasosa-espectrometria de massa [PDF]

, 2007
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia AmbientalEsse trabalho tem como objetivo contribuir para a elaboração de uma metodologia de análise da concentração odorante no Limite ...
Muniz, Ana Cristina Silva
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source