Results 211 to 220 of about 1,701,351 (292)

Matrix Rigidity Mechanoprimes Microglia for Inflammation Through Cytoskeletal‐to‐Nuclear Signaling and 3D Spatio‐Epigenomic Remodeling

open access: yesAdvanced Science, EarlyView.
Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng   +15 more
wiley   +1 more source

Molecular Atlas of Key Food Odorants Reveals Mixture‐Level Organization and Enables Generative Aroma Design

open access: yesAdvanced Science, EarlyView.
KFO‐Atlas reveals how real‐world aromas are organized as structured mixtures rather than individual molecules. Building on these principles, KFO‐Gen, a generative AI framework, designs perceptually valid aroma formulations and reconstructs meat‐like aromas exclusively from plant‐derived odorants, providing a foundation for mixture‐level studies and AI ...
Jingzhi Zhang   +5 more
wiley   +1 more source

The recent findings in the off-flavors of beer

open access: yesJournal of Japan Association on Odor Environment, 2013
openaire   +2 more sources

Synergistic Effects in Multistate Black Electro‐Thermochromic Smart Windows for Energy‐Efficient Modulation of Solar Heating

open access: yesAdvanced Science, EarlyView.
Hybrid electro‐thermochromic smart windows are developed for dynamic climate control by integrating a redox‐matched black electrochromic gel with a paraffin‐based thermochromic film. This synergistic combination enables multimodal solar modulation, where photothermal heating from the electrochromic layer triggers thermochromic activation at lower ...
Xilu Wu   +12 more
wiley   +1 more source

Spontaneous Cyclic Levitation of Glycerol‐Water Droplets at Low Pressures

open access: yesAdvanced Science, EarlyView.
Under low pressure, a minute glycerol addition transforms the chaotic dynamics of freezing water droplets into cyclic levitation. Freeze‐concentration preserves liquid pathways that relax expansion‐induced stress, while freezing point depression weakens asymmetric vaporization recoil.
Chen Xu   +10 more
wiley   +1 more source

Predicting Enzyme Turnover Numbers and Enabling Rational Enzyme Evolution

open access: yesAdvanced Science, EarlyView.
MCKcat, a deep learning framework combining multi‐scale convolution and cross‐attention, accurately predicts enzyme turnover number (kcat) by fusing sequence and reaction representations. It couples with rational design in a two‐step strategy for Bacillus aryabhattai laccase engineering, achieving a 75% positive rate with synergistically enhanced ...
Fengya Ge   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy