Results 111 to 120 of about 1,639,925 (354)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
From Construction to Production: Enablers, Barriers and Opportunities for the Highways Supply Chain [PDF]
, 2017 The report presents the initial findings of a project part of the Lean Collaborative Research at Highways England with academia that aims at understanding enablers, barriers and opportunities to transform the current highways construction supply chain ...
Gosling, Jonathan +3 more
core
Developing a worker engagement maturity model for improving occupational safety and health (OSH) in construction [PDF]
, 2017 Research on worker engagement (WE) has identified the increased importance of meaningful discussion, communication, knowledge sharing, and shared decision-making regarding occupational safety and health (OSH) practices within the construction industry ...
Cameron, Iain +2 more
core +3 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Drivers constraints and the future of off-site manufacture in Australia. [PDF]
, 2007 Much has been written on Off-site Manufacture (OSM) in construction, particularly regarding the perceived benefits and barriers to implementation. However, very little understanding of the state of OSM in the Australian construction industry exists. A ‘
Blismas, Nick, Wakefield, Ron
core +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Modular Construction to Support Airport Sustainability at US Airports
Future TransportationThis paper explores how modular construction can enhance airport sustainability, highlighting example applications at US airports. Whereas traditional construction builds sequentially on-site, modular construction (also known as prefabricated, off-site ...
Sarah Hubbard
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Improving the evaluation of web search systems [PDF]
, 2003 Linkage analysis as an aid to web search has been assumed to be of significant benefit and we know that it is being implemented by many major Search Engines.
Gurrin, Cathal, Smeaton, Alan F.
core +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source