Results 121 to 130 of about 1,639,925 (354)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

The visual, the accidental and the actual in the historiography of the fort of Shinkakasa, Democratic Republic of Congo, 1891- 1909 [PDF]

open access: yes, 2019
Much against the advice of his military counsellors about static fortifications being obsolete in an age and continent of gunboat diplomacy, the Belgian king Leopold II took a resolute stand.
Bekers, Willem, Fivez, Robby
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Improving Construction Meeting Effectiveness: A Trade-Off between Reactive and Proactive Site-Level Planning Discussions

open access: green, 2023
Ashtad Javanmardi   +4 more
openalex   +1 more source

Mitigation of Greenhouse Gas Emissions from Urban Environmental Infrastructures [PDF]

open access: yes, 2018
The world’s population will increase to 9.4 billion people by 2050 and 70% of whom will be living in urban areas. Such urbanization with population growth and industrial development demands in turn create a need for the planning, design, and construction
KIm, Jongkon   +2 more
core  

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Developing an uncertainty analysis model for off-site building production [PDF]

open access: yes
The hybrid use of off-site and on-site processes in construction projects has increased significantly over the past decade. The analysis and management of uncertainty in hybrid projects is not a trivial task as workflow variability in off-site and on ...
Arashpour, M, Wakefield, R
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Oyster Reef Restoration Project for the City of Dover, Grizzle [PDF]

open access: yes, 2006
This project was conducted as a contract between the City of Dover and the University of New Hampshire, with additional funding supplied by the New Hampshire Estuaries Project.
Abeels, Holly   +2 more
core   +2 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

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