Results 181 to 190 of about 14,685,807 (300)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Editorial: Precise Genome Editing Techniques and Applications

Frontiers in Genetics, 2020
Kun Xu, David Jay Segal, Zhiying Zhang
doaj   +1 more source

Potential Off-Target Effect of Gilteritinib With Venetoclax Decreases Tumor Burden for Patients With Relapsed/Refractory Wild-Type <i>FLT3</i> Acute Myeloid Leukemia/Myelodysplastic Neoplasms. [PDF]

Case Rep Hematol
Chang S, Pan Z, Zhang Y, Zhang Y, Sun J, Guo Y, Guo X, Guo Z.   +7 more
europepmc   +1 more source

Off-target effects of RAAS-inhibition

, 2012
De effectiviteit van nieuw te ontwikkelen medicijnen voor patiënten met diabetes en nierziekte wordt doorgaans beoordeeld op basis van een enkele risicofactor voor nierziekte en hart- en vaatziekte (de zogenaamde on-target risico factor). Daarnaast worden verschillende parameters geëvalueerd om de veiligheid van het geneesmiddel vast te stellen.
openaire   +1 more source

“Off-target” effect of tamoxifen on the brain [PDF]

Lab Animal, 2020
openaire   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

An off-target effect of class A CpG-oligonucleotides on suppressing the cyclic GMP-AMP synthase signaling in fibroblastic reticular cells. [PDF]

Front Pharmacol
Jayakumar P, Jiang T, Huang H, Deng M.
europepmc   +1 more source

Off-target effect of the BMI1 inhibitor PTC596 drives epithelial-mesenchymal transition in glioblastoma multiforme. [PDF]

NPJ Precis Oncol, 2020
Flamier A, Abdouh M, Hamam R, Barabino A, Patel N, Gao A, Hanna R, Bernier G.   +7 more
europepmc   +1 more source

Pharmacogenomics of off-target adverse drug reactions

, 2017
Off-target adverse drug reactions (ADRs) are associated with significant morbidity and costs to the healthcare system, and their occurrence is not predictable based on the known pharmacological action of the drug's therapeutic effect. Off-target ADRs may
Garon, S.L., White, K.D., Brown, N.J., Stone, C.A., Phillips, E.J., Pavlos, R.K.   +5 more
core  

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source