Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
High On-Off Ratio Bilayer Graphene Complementary Field Effect Transistors
, 2010 In this paper, we propose a novel S/D engineering for dual-gated Bilayer Graphene (BLG) Field Effect Transistor (FET) using doped semiconductors (with a bandgap) as source and drain to obtain unipolar complementary transistors.
Xia, Fengnian +4 more
core
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
OFF-SITE COSTS OF SOIL EROSION: A CASE STUDY IN THE WILLAMETTE VALLEY [PDF]
This study attempts to provide relative magnitudes of average and marginal costs of off-site sediment-related costs in OregonÂ’s Willamette Valley. Water treatment; road, river channel, and dam maintenance; and hydroelectric generation are examined. Road
McCarl, Bruce A., Moore, Walter B.
core
Potential Off-Target Effect of Gilteritinib With Venetoclax Decreases Tumor Burden for Patients With Relapsed/Refractory Wild-Type <i>FLT3</i> Acute Myeloid Leukemia/Myelodysplastic Neoplasms. [PDF]
Case Rep HematolChang S +7 more
europepmc +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Editorial: Precise Genome Editing Techniques and Applications
Frontiers in Genetics, 2020 Kun Xu, David Jay Segal, Zhiying Zhang
doaj +1 more source
An off-target effect of class A CpG-oligonucleotides on suppressing the cyclic GMP-AMP synthase signaling in fibroblastic reticular cells. [PDF]
Front PharmacolJayakumar P, Jiang T, Huang H, Deng M.
europepmc +1 more source
Off-target effect of the BMI1 inhibitor PTC596 drives epithelial-mesenchymal transition in glioblastoma multiforme. [PDF]
NPJ Precis Oncol, 2020 Flamier A +7 more
europepmc +1 more source