Results 41 to 50 of about 12,631,699 (241)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Offset-Free Strategy by Double-Layered Linear Model Predictive Control [PDF]

, 2020
In the real applications, the model predictive control MPC technology is separated into two layers, that is, a layer of conventional dynamic controller, based on which is an added layer of steady-state target calculation.
Tao Zou
core  

Dispersion effects on performance of the free-electron laser FLASH

Physical Review Special Topics. Accelerators and Beams, 2010
This paper studies the impact of transverse dispersion on the free-electron laser (FEL) performance in two main aspects: radiation power sensitivity to electron beam energy offset and radiation wavelength spectrum.
Eduard Prat, Winfried Decking, Torsten Limberg   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Offset-free model predictive control for enhancing MR-HIFU hyperthermia in cancer treatment⁎

, 2018
In this paper, an offset-free MPC scheme is developed to improve performance and robustness of temperature control in magnetic resonance-guided high-intensity focused ultrasound hyperthermia cancer treatments.
Heijman, E., Deenen, D. A., Heemels, W. P.M.H., Sebeke, L., Maljaars, E., de Jager, Bram, Grüll, H.   +6 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Coherent Beam Combining Using an Internally Sensed Optical Phased Array of Frequency-Offset Phase Locked Lasers

Photonics, 2020
Coherent beam combining can be used to scale optical power and enable mechanism-free beam steering using an optical phased array. Coherently combining multiple free-running lasers in a leader-follower laser configuration is challenging due to the need to
Lyle E. Roberts, Robert L. Ward, Craig Smith, Daniel A. Shaddock   +3 more
doaj   +1 more source

Model‐free adaptive integral sliding mode constrained control with modified prescribed performance

IET Control Theory & Applications, 2023
In this work, a novel model‐free adaptive integral sliding model constrained control strategy with modified prescribed performance is proposed for nonlinear nonaffine systems via full‐form dynamic linearization (FFDL).
Xiuwei Huang, Zhiyan Dong, Feng Zhang, Lihua Zhang   +3 more
doaj   +1 more source