Results 51 to 60 of about 23,175 (239)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
IEEE Access, 2020 Envision a ubiquitously device-free motion sensing, this work focuses on the analysis of Wi-Fi-based hand gesture trajectory tracking by utilizing the Doppler frequency obtained from channel state information (CSI).
Nopphon Keerativoranan +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
应用气象学报, 2023 Solar irradiance is one important element in conventional meteorology observations. Long-term observations of solar radiation by using China-made wide-band pyranometers have been carried out.
Zheng Xiangdong, Zhao Yong
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Robust Model Predictive Control of a Plate Heat Exchanger
Chemical Engineering Transactions, 2018 Advanced process control includes optimization-based tools that are recently widely implemented in industry to maximize economical effectiveness and to minimize environmental impact. Robust model predictive control (MPC) is one of these strategies and it
Juraj Oravec +3 more
doaj +1 more source
Efficient Convex-Lifting-Based Robust Control of a Chemical Reactor
Chemical Engineering Transactions, 2020 Efficient operation of chemical reactors is a very challenging task. Continuous stirred-tank reactors (CSTRs) are important devices of the process industry. CSTRs have complex non-linear behaviour.
Michaela Horváthová +2 more
doaj +1 more source