Results 41 to 50 of about 23,359 (238)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Offset-Free Model Predictive Control for Active Magnetic Bearing Systems

Actuators, 2018
This paper presents the study of linear Offset-Free Model Predictive Control (OF-MPC) for an Active Magnetic Bearing (AMB) application. The method exploits the advantages of classical MPC in terms of stability and control performance and, at the same ...
Angelo Bonfitto, Luis Miguel Castellanos Molina, Andrea Tonoli, Nicola Amati   +3 more
doaj   +1 more source

Intrafraction Prostate Motion Management During Dose-Escalated Linac-Based Stereotactic Body Radiation Therapy

Frontiers in Oncology, 2022
BackgroundExtreme hypofractionation requires tight planning margins, high dose gradients, and strict adherence to planning criteria in terms of patient positioning and organ motion mitigation.
Denis Panizza, Denis Panizza, Valeria Faccenda, Valeria Faccenda, Raffaella Lucchini, Raffaella Lucchini, Martina Camilla Daniotti, Martina Camilla Daniotti, Sara Trivellato, Paolo Caricato, Paolo Caricato, Valerio Pisoni, Elena De Ponti, Elena De Ponti, Stefano Arcangeli, Stefano Arcangeli   +15 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Learning to Detect Objects from Eye-Tracking Data [PDF]

i-Perception, 2014
One of the bottlenecks in computer vision, especially in object detection, is the need for a large amount of training data. Typically, this is acquired by manually annotating images by hand. In this study, we explore the possibility of using eye-trackers
D.P Papadopoulous, A.D.F Clarke, F Keller, V Ferrari   +3 more
doaj   +1 more source

Optimal metaheuristic state-dependent parameter proportional-integral-plus control: Alternative to gain-scheduled controller for control of a nonlinear continuous stirred tank reactor

Systems and Soft Computing, 2023
The continuous stirred-tank reactors have complex dynamic behavior. In the reactor, the residual concentration decreases during an exothermic chemical reaction.
Behrouz Kiani Talaei, Farhad Shahraki, Jafar Sadeghi, Mir Mohammad Khalilipour   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source