Results 51 to 60 of about 861,121 (278)

SAT-158 Offspring Exposed to Maternal High Fat Diet Exhibits Systemic Inflammation and Pancreatic Islet Dysfunction [PDF]

, 2019
Offspring born to overweight mothers are more likely to develop dysregulated immune response1, obesity1 and pancreatic islet dysfunction2. These offspring have increased inflammation at birth3 and at least until childhood4. We hypothesize that heightened
Casasnovas, Jose, Jarrell, James, Kua, Kok Lim, Pineros, Annie   +3 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

STYXL1 regulates CCT complex assembly and flagellar tubulin folding in sperm formation

Nature Communications
Tubulin-based microtubule is a core component of flagella axoneme and essential for sperm motility and male fertility. Structural components of the axoneme have been well explored.
Yu Chen, Mengjiao Luo, Haixia Tu, Yaling Qi, Yueshuai Guo, Xiangzheng Zhang, Yiqiang Cui, Mengmeng Gao, Xin Zhou, Tianyu Zhu, Hui Zhu, Chenghao Situ, Yan Li, Xuejiang Guo   +13 more
doaj   +1 more source

Sperm storage by males causes changes in sperm phenotype and influences the reproductive fitness of males and their sons [PDF]

, 2017
Recent studies suggest that environmentally induced effects on sperm phenotype can influence offspring phenotype beyond the classic Mendelian inheritance mechanism.
Adriaenssens, Aitken, Almbro, Bonduriansky, Bonduriansky, Boschetto, Crean, Crean, Crean, Curley, El Jack, Evans, Evans, Evans, Evans, Falconer, Firman, Franco, Froman, Gasparini, Gasparini, Gasparini, Gasparini, Head, Holt, Houde, Immler, Immler, Jensen, Jones, Kilgallon, Lynch, Marshall, Orr, Parker, Perry, Pilastro, Pilastro, Pilastro, Pizzari, Poiani, R Development Core Team, Rahman, Rahman, Reinhardt, Reinhardt, Sheldon, Simmons, Simmons, Siva-Jothy, Tan, Tarin, Vasudeva, White, Zajitschek   +54 more
core   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

A latent class analysis of parental bipolar disorder: examining associations with offspring psychopathology [PDF]

, 2015
Bipolar disorder (BD) is highly heterogeneous, and course variations are associated with patient outcomes. This diagnostic complexity challenges identification of patients in greatest need of intervention.
Freed, Rachel D., Henin, Aude, Nierenberg, Andrew A., Otto, Michael W., Tompson, Martha C.   +4 more
core   +1 more source

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

Associations of maternal dietary iron intake during pregnancy with infant neurodevelopment: evidence from a prospective cohort study

Nutrition Journal
Background Iron, an essential micronutrient, plays a critical role in fetal neurodevelopment. Animal studies have demonstrated that maternal iron-deficient diets during pregnancy induce permanent structural and functional alterations in offspring brains.
Rui Qin, Liya Pang, Haiting Hu, Yangqian Jiang, Hong Lv, Kan Ye, Cong Liu, Xin Xu, Xiaoyu Liu, Kun Zhou, Tao Jiang, Jiangbo Du, Lingmin Hu, Zhibin Hu, Zhonghua Shi, Yuan Lin   +15 more
doaj   +1 more source

Human Brain Vasculature‐on‐a‐Chip Model Constructed With Microvessels Isolated From Cryopreserved Postmortem Human Brain Tissue

Advanced Healthcare Materials, EarlyView.
This manuscript describes the cultivation of viable microvessels from cryopreserved human brain tissue. When embedded in hydrogels and cultured in microfluidic devices, these microvessels exhibit complex architectures reminiscent of arterioles and capillaries, can be perfused, and display intact barrier function. Collectively, these results demonstrate
Brian J. O'Grady, A. Scott McCall, Samuel Cullison, Daniel Chavarria, Matthew S. Schrag, Ethan S. Lippmann   +5 more
wiley   +1 more source

Artists' offspring [PDF]

Nature, 1992
L V, Rubinstein, A D, Koutsoukos
openaire   +4 more sources