Results 1 to 10 of about 27,515 (197)

Factors Influencing Practitioners’ Experience of Utilizing Open Government Data [PDF]

open access: yesJournal of Library and Information Studies, 2023
Open government data (OGD) has been discussed globally for its value in improving the government’s service quality and transparency. However, most OGD must be utilized by the practitioners in their projects so that the public can benefit from the ...
Wei-Chung Cheng, Ming-Hsin Phoebe Chiu
doaj   +1 more source

Correlation between granulocyte colony-stimulating factor and the Notch signaling pathway in ischemic brain injury

open access: yesArchives of Medical Science, 2021
Introduction This study aimed to determine the relationship between granulocyte colony-stimulating factor (G-CSF) and the Notch signaling pathway in ischemic brain injury.
Ning Xie   +3 more
doaj   +1 more source

Complete inhibition of phosphatase and tensin homolog promotes the normal and oxygen-glucose deprivation/reperfusion-injured PC12 cells to cell death [PDF]

open access: yesJournal of Cardiovascular and Thoracic Research, 2018
Introduction: Lipid phosphatase and tensin homolog deleted from chromosome 10 (PTEN) antagonizes phosphoinositide 3-kinase (PI3K)/AKT cell survival pathway.
Sohrab Minaei Beyrami   +4 more
doaj   +1 more source

Physiologically‐based pharmacokinetic modeling to support bioequivalence and approval of generic products: A case for diclofenac sodium topical gel, 1%

open access: yesCPT: Pharmacometrics & Systems Pharmacology, 2021
Establishing bioequivalence (BE) for dermatological drug products by conducting comparative clinical end point studies can be costly and the studies may not be sufficiently sensitive to detect certain formulation differences.
Eleftheria Tsakalozou   +2 more
doaj   +1 more source

Regulatory utility of physiologically‐based pharmacokinetic modeling to support alternative bioequivalence approaches and risk assessment: A workshop summary report

open access: yesCPT: Pharmacometrics & Systems Pharmacology, 2023
This report summarizes the proceedings for day 2 sessions 1 and 3 of the 2‐day public workshop entitled “Regulatory Utility of Mechanistic Modeling to Support Alternative Bioequivalence Approaches,” a jointly sponsored workshop by the US Food and Drug ...
Fang Wu   +17 more
doaj   +1 more source

Modified Oesophago-Gastric Dissociation (M-OGD) — a technical modification [PDF]

open access: yesUpdates in Surgery, 2020
AbstractAdhesions and fibrosis following failed primary surgery for severe gastro-oesophageal reflux (GOR) in neurologically impaired children (NI) can render mobilization of the lower oesophagus and oesophago-jejunal anastomosis a technically demanding exercise both at open surgery and laparoscopy.
Coletta R.   +3 more
openaire   +3 more sources

Cell death pathways in astrocytes with a modified model of oxygen-glucose deprivation. [PDF]

open access: yesPLoS ONE, 2013
Traditional oxygen-glucose deprivation (OGD) models do not produce sufficiently stable and continuous deprivation to induce cell death in the ischemic core.
Qiaoying Huang   +4 more
doaj   +1 more source

Heat Shock Protein 70 Protects the Heart from Ischemia/Reperfusion Injury through Inhibition of p38 MAPK Signaling. [PDF]

open access: yes, 2020
BackgroundHeat shock protein 70 (Hsp70) has been shown to exert cardioprotection. Intracellular calcium ([Ca2+]i) overload induced by p38 mitogen-activated protein kinase (p38 MAPK) activation contributes to cardiac ischemia/reperfusion (I/R) injury ...
Chen, Qing-Cai   +10 more
core   +1 more source

Surgical OGD – a dying art? [PDF]

open access: yesAnnals of The Royal College of Surgeons of England, 2003
Reductions in surgical training and the increases in medical gastroenterology have raised concerns that surgeons may not be adequately trained in upper gastrointestinal (GI) endoscopy.To evaluate this problem, a questionnaire was sent to all current surgical specialist registrars (SpRs) in the South Thames East Region.There was an 82% (52/63) response ...
R E, Bell, N J, Griffiths, T, Bates
openaire   +2 more sources

Mechanistic modeling of drug products applied to the skin: A workshop summary report

open access: yesCPT: Pharmacometrics & Systems Pharmacology, 2023
The development of a generic drug product involves demonstrating that there is no significant difference in the rate and extent to which the active ingredient becomes available at the site of action, relative to the reference listed drug product.
Eleftheria Tsakalozou   +9 more
doaj   +1 more source

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