Results 91 to 100 of about 11,397 (216)

Triphlorethol-A from Ecklonia cava Up-Regulates the Oxidant Sensitive 8-Oxoguanine DNA Glycosylase 1

Marine Drugs, 2014
This study investigated the protective mechanisms of triphlorethol-A, isolated from Ecklonia cava, against oxidative stress-induced DNA base damage, especially 8-oxoguanine (8-oxoG), in Chinese hamster lung fibroblast V79-4 cells.
Ki Cheon Kim, In Kyung Lee, Kyoung Ah Kang, Mei Jing Piao, Min Ju Ryu, Jeong Mi Kim, Nam Ho Lee, Jin Won Hyun   +7 more
doaj   +1 more source

Inter-individual variation in DNA repair capacity: A need for multi-pathway functional assays to promote translational DNA repair research [PDF]

, 2014
Why does a constant barrage of DNA damage lead to disease in some individuals, while others remain healthy? This article surveys current work addressing the implications of inter-individual variation in DNA repair capacity for human health, and discusses
Chaim, Isaac Alexander, Nagel, Zachary D., Samson, Leona D   +2 more
core   +1 more source

Human 8-oxoguanine glycosylase OGG1 binds nucleosome at the dsDNA ends and the super-helical locations

Communications Biology
The human glycosylase OGG1 extrudes and excises the oxidized DNA base 8-oxoguanine (8-oxoG) to initiate base excision repair and plays important roles in many pathological conditions such as cancer, inflammation, and neurodegenerative diseases.
Qinglong You, Xiang Feng, Yi Cai, Stephen B. Baylin, Huilin Li   +4 more
doaj   +1 more source

OGG1-driven pathogenesis in Kawasaki disease: Identification and pharmacological regulation of a molecular marker validated in transgenic mice and clinical models

Pharmacological Research
Kawasaki disease (KD) is an acute systemic vasculitis affecting children and leads to severe coronary artery complications, such as aneurysms. The cause of KD remains elusive, with infections suspected as potential triggers.
Xiaoyun Yun, Liqun Qu, Hanghong Lo, Jianhui Wu, Wu Zeng, Ka In U, Yan Chen, Baoquan Pan, Bin Tang, Wei Zhang, Yuping Wang, Xiongfei Xu, Jie Zhou, Wendy WL Hsiao, Vincent Kam Wai Wong, Cheng Lei, Betty Yuen Kwan Law   +16 more
doaj   +1 more source

MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis

Scientific Reports, 2021
8-Oxoguanine (8-oxoG), a major oxidative base lesion, is highly accumulated in Alzheimer’s disease (AD) brains during the pathogenic process. MTH1 hydrolyzes 8-oxo-dGTP to 8-oxo-dGMP, thereby avoiding 8-oxo-dG incorporation into DNA.
Sugako Oka, Julio Leon, Kunihiko Sakumi, Nona Abolhassani, Zijing Sheng, Daisuke Tsuchimoto, Frank M. LaFerla, Yusaku Nakabeppu   +7 more
doaj   +1 more source

Primary Human Tissue Models for Metabolic Dysfunction‐Associated Liver Disease ‐ toward Streamlining Drug Discovery with Patient‐Derived Assays

Advanced Biology, Volume 9, Issue 12, December 2025.
The review provides a critical up‐to‐date overview of the current landscape of human in vitro models for fatty liver disease, including spheroids, organoids, organ‐on‐a‐chip systems, bioprinted liver constructs and precision‐cut liver slices. Their utility for faithfully modeling different stages of MASLD and MASH are evaluated and their compatibility ...
Sonia Youhanna, Nayere Taebnia, Yingxin Liang, Ningtao Cheng, Yi Wang, Maurice Michel, Volker M. Lauschke   +6 more
wiley   +1 more source

Association of the OGG1 Ser326Cys polymorphism with tooth loss [PDF]

Journal of Clinical Laboratory Analysis, 2006
AbstractAlthough tooth loss is a serious health problem for elderly people, little is known about the genetic basis for susceptibility to it. In the present study we aimed to find a single nucleotide polymorphism (SNP) associated with tooth loss.
Yoshinori, Hasui, Yuichiro, Hamanaka, Naoko, Okayama, Yutaka, Suehiro, Fumihiko, Shinozaki, Yoshiya, Ueyama, Yuji, Hinoda   +6 more
openaire   +2 more sources

Comprehensive Measurement of Inter‐Individual Variation in DNA Repair Capacity in Healthy Individuals

Advanced Science, Volume 12, Issue 47, December 18, 2025.
Susceptibility to the health effects of DNA damage depends on a person's ability to repair DNA damage, but DNA repair has been difficult to measure in populations. A functional assay called FM‐HCR is used to measure DNA repair in 6 major pathways across 56 individuals.
Ting Zhai, Patrizia Mazzucato, Catherine Ricciardi, David C. Christiani, Liming Liang, Leona D. Samson, Isaac A. Chaim, Zachary D. Nagel   +7 more
wiley   +1 more source

Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice

Cell Reports, 2015
Ogg1 and Mutyh DNA glycosylases cooperate to prevent mutations caused by 8-oxoG, a major premutagenic DNA lesion associated with cognitive decline. We have examined behavior and cognitive function in mice deficient of these glycosylases.
Monica D. Bjørge, Gunn A. Hildrestrand, Katja Scheffler, Rajikala Suganthan, Veslemøy Rolseth, Anna Kuśnierczyk, Alexander D. Rowe, Cathrine B. Vågbø, Susanne Vetlesen, Lars Eide, Geir Slupphaug, Yusaku Nakabeppu, Timothy W. Bredy, Arne Klungland, Magnar Bjørås   +14 more
doaj   +1 more source

DNA glycosylases: in DNA repair and beyond [PDF]

, 2018
The base excision repair machinery protects DNA in cells from the damaging effects of oxidation, alkylation, and deamination; it is specialized to fix single-base damage in the form of small chemical modifications. Base modifications can be mutagenic and/
Jacobs, Angelika, Schär, Primo
core