Results 71 to 80 of about 5,940 (176)

Human 8-oxoguanine glycosylase OGG1 binds nucleosome at the dsDNA ends and the super-helical locations

Communications Biology
The human glycosylase OGG1 extrudes and excises the oxidized DNA base 8-oxoguanine (8-oxoG) to initiate base excision repair and plays important roles in many pathological conditions such as cancer, inflammation, and neurodegenerative diseases.
Qinglong You, Xiang Feng, Yi Cai, Stephen B. Baylin, Huilin Li   +4 more
doaj   +1 more source

MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis

Scientific Reports, 2021
8-Oxoguanine (8-oxoG), a major oxidative base lesion, is highly accumulated in Alzheimer’s disease (AD) brains during the pathogenic process. MTH1 hydrolyzes 8-oxo-dGTP to 8-oxo-dGMP, thereby avoiding 8-oxo-dG incorporation into DNA.
Sugako Oka, Julio Leon, Kunihiko Sakumi, Nona Abolhassani, Zijing Sheng, Daisuke Tsuchimoto, Frank M. LaFerla, Yusaku Nakabeppu   +7 more
doaj   +1 more source

MUTYH Cancer‐Associated Variants Within the Interdomain Connector Differentially Impact Glycosylase Activity and Cellular DNA Repair

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Functional analysis of cancer‐associated variants of the DNA repair enzyme MUTYH in the interdomain connector between the 8‐oxoguanine (OG) recognition and base excision domains reveals discordance between in vitro assays and OG:A repair in cells. This disconnect highlights the use of complementary biochemical and cellular assays to accurately classify
Cindy Khuu, Melody Malek, Savannah G. Conlon, Geoffrey P. Wadey, Carlos H. Trasviña‐Arenas, Sheila S. David   +5 more
wiley   +1 more source

Triphlorethol-A from Ecklonia cava Up-Regulates the Oxidant Sensitive 8-Oxoguanine DNA Glycosylase 1

Marine Drugs, 2014
This study investigated the protective mechanisms of triphlorethol-A, isolated from Ecklonia cava, against oxidative stress-induced DNA base damage, especially 8-oxoguanine (8-oxoG), in Chinese hamster lung fibroblast V79-4 cells.
Ki Cheon Kim, In Kyung Lee, Kyoung Ah Kang, Mei Jing Piao, Min Ju Ryu, Jeong Mi Kim, Nam Ho Lee, Jin Won Hyun   +7 more
doaj   +1 more source

OGG1-driven pathogenesis in Kawasaki disease: Identification and pharmacological regulation of a molecular marker validated in transgenic mice and clinical models

Pharmacological Research
Kawasaki disease (KD) is an acute systemic vasculitis affecting children and leads to severe coronary artery complications, such as aneurysms. The cause of KD remains elusive, with infections suspected as potential triggers.
Xiaoyun Yun, Liqun Qu, Hanghong Lo, Jianhui Wu, Wu Zeng, Ka In U, Yan Chen, Baoquan Pan, Bin Tang, Wei Zhang, Yuping Wang, Xiongfei Xu, Jie Zhou, Wendy WL Hsiao, Vincent Kam Wai Wong, Cheng Lei, Betty Yuen Kwan Law   +16 more
doaj   +1 more source

High Intrinsic Aerobic Capacity Is Associated With a Distinct Epigenetic and Signaling Profile in the Aged Rat Brain

Aging Cell, Volume 25, Issue 7, July 2026.
High intrinsic aerobic capacity in aged rats is associated with a hypermethylation‐enriched hippocampal DMR profile, mainly involving open‐sea and gene‐body‐associated regions, together with cortical MAPK, AKT‐mTOR‐S6, synaptic, and inflammation‐related protein signaling changes.
Lei Zhou, Soroosh Mozaffaritabar, Erika Koltai, Takuji Kawamura, Mitsuru Higuchi, Sylwester Kujach, Yaodong Gu, Lauren Gerard Koch, Steven Loyal Britton, Zsolt Radák   +9 more
wiley   +1 more source

Conservation Status of Two Italian Local Poultry Breeds: Faraona Camosciata and Oca Padovana

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT The present study aimed to assess the conservation status and characterize the phenotypic and genomic diversity of two endangered Italian poultry genetic resources to guide their conservation plans. Blood samples and morphometric data were collected on 50 Faraona Camosciata (FAC, Numida meleagris) and 50 Oca Padovana (OPD, Anser anser) adult ...
Filippo Cendron, Enrico Bortoletto, Francesco Perini, Maristella Baruchello, Umberto Rosani, Emiliano Lasagna, Martino Cassandro, Mauro Penasa   +7 more
wiley   +1 more source

Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice

Cell Reports, 2015
Ogg1 and Mutyh DNA glycosylases cooperate to prevent mutations caused by 8-oxoG, a major premutagenic DNA lesion associated with cognitive decline. We have examined behavior and cognitive function in mice deficient of these glycosylases.
Monica D. Bjørge, Gunn A. Hildrestrand, Katja Scheffler, Rajikala Suganthan, Veslemøy Rolseth, Anna Kuśnierczyk, Alexander D. Rowe, Cathrine B. Vågbø, Susanne Vetlesen, Lars Eide, Geir Slupphaug, Yusaku Nakabeppu, Timothy W. Bredy, Arne Klungland, Magnar Bjørås   +14 more
doaj   +1 more source

Stressed Overwintering Bottleneck Hypothesis: Ocean Warming and Acidification Synergistically Disrupt Arctic Zooplankton Overwintering

Global Change Biology Communications, Volume 1, Issue 2, June 2026.
Ocean warming (OW) and acidification (OA) synergistically doubled overwintering Calanus glacialis mortality and increased DNA damage. OW accelerated moulting by mid‐Polar Night, boosted metabolism, depleted lipids by early March, 1–4 months pre‐spring algal bloom, and amplified oxidative damage. Collectively, these stressors cause overwintering failure,
Jildou Dijkstra, Janne E. Søreide, Luise Schott, Nele Thomsen, Helena Reinardy, Mathieu Lutier, Khuong V. Dinh   +6 more
wiley   +1 more source

Ogg1 regulates TGF‑β–Smad3 signalling and fibrosis progression in chronic kidney disease

Communications Biology
Kidney fibrosis is a hallmark of chronic kidney disease (CKD) and a major contributor to progression toward end-stage renal disease. Here, we identify 8-oxoguanine DNA glycosylase 1 (Ogg1), a DNA repair enzyme, as a regulator of kidney fibrosis.
Ying Wang, Yan Liu, Bo Peng, Chan Zou, Guoping Yang, Jiefu Zhu, Hao Zhang, Jing Huang   +7 more
doaj   +1 more source