Relation between DNA damage measured by comet assay and OGG1 Ser326Cys polymorphism in antineoplastic drugs biomonitoring [PDF]
, 2015 Antineoplastic drugs are hazardous chemical agents used mostly in the treatment of patients with cancer, however health professionals that handle and administer these drugs can become exposed and develop DNA damage.
Brito, Miguel +5 more
core +3 more sources
Dualistic Roles of High Mobility Group Box 1 in Cancer and Inflammation
Cancer Medicine, Volume 14, Issue 23, December 2025.ABSTRACT Background The High Mobility Group Box 1 (HMGB1) protein, a member of the HMG family, plays a crucial role in both cancer progression and inflammatory responses. HMGB1 can act as a damage‐associated molecular pattern (DAMP) to activate immune responses and modulate inflammation.
Wen Zeng +6 more
wiley +1 more source
Comet assay as a human biomonitoring tool: application in occupational exposure to antineoplastic drugs [PDF]
, 2015 Antineoplastic drugs are a heterogeneous group of chemicals used in the treatment of cancer, and have been proved by IARC to be mutagens, carcinogens and teratogens agents.
Brito, Miguel +5 more
core +1 more source
MedComm, Volume 6, Issue 12, December 2025.Radiation‐induced biological effects are an extremely complex and extensive mechanism that involves multiple aspects of physiological activities in organisms. In the medical field, utilizing the damaging effects of radiation to treat tumors is a commonly employed therapeutic approach.
Zhihe Hu +5 more
wiley +1 more source
Phi-score: A cell-to-cell phenotypic scoring method for sensitive and selective hit discovery in cell-based assays [PDF]
, 2015 International audiencePhenotypic screening monitors phenotypic changes induced by perturbations, including those generated by drugs or RNA interference.
Bhajun, Ricky +13 more
core +4 more sources
Rad51 at the Crossroads: Bridging DNA Repair, Tumorigenesis, and Immune Regulation
Med Research, Volume 1, Issue 3, Page 359-377, December 2025.Therapeutic landscape of Rad51 in cancer treatment. Key elements include (1) DNA damage sources (PARPi, chemo/radiotherapy); (2) repair pathways (Rad51‐mediated HR); (3) intervention strategies (Rad51 inhibitors, CRISPR/Cas9); and (4) combination approaches (immunotherapy). The figure is created with BioRender.com.
Zhendong Qin +4 more
wiley +1 more source
8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1 [PDF]
, 2013 8-Oxo-7,8-dihydroguanine (8-oxoG) is one of the most abundant DNA base lesions induced by reactive oxygen species (ROS). Accumulation of 8-oxoG in the mammalian genome is considered a marker of oxidative stress, to be causally linked to inflammation, and
Aguilera-Aguirre, Leopoldo +8 more
core +1 more source
MedComm – Future Medicine, Volume 4, Issue 4, December 2025.Air pollution, a major global health hazard, contributes to asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and lung cancer via four core epigenetic pathways (DNA/RNA methylation, noncoding RNAs, and histone modifications), shaping gene expression and driving disease pathogenesis.
Ruitong Zeng +6 more
wiley +1 more source
Application of alkaline comet assay in human biomonitoring for genotoxicity: a study on occupational exposure to cytostatics [PDF]
, 2014 The use of cytostatics drugs in anticancer therapy is increasing. Health care workers can be occupationally exposed to these drugs classified as carcinogenic, mutagenic or teratogenic.
Brito, Miguel +4 more
core
Small intestinal development in suckling rats after enteral obestatin administration [PDF]
, 2018 This study investigated the effect of enteral administration of obestatin on the development of small intestine, as well as oxidative stress markers and trancriptomic profile of gastrointestinal genes. Suckling rats were assigned to 3 groups treated with:
Grzesiak, Paulina +8 more
core +1 more source